Piché L A, Draper H H, Cole P D
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
Lipids. 1988 Apr;23(4):370-1. doi: 10.1007/BF02537352.
Urinary malondialdehyde (MDA), an indicator of lipid peroxidation in the diet and in the tissues, was determined in human adults consuming a supplement of n-3 fatty acids derived from a pharmaceutical grade of cod liver oil (CLO) without added antioxidants vs a concentrate of n-3 acids containing dodecyl gallate and vitamin E. MDA excretion increased immediately in the subjects consuming CLO but remained unchanged in those ingesting the concentrate for 50 days. The increase in the subjects taking CLO was attributable to MDA in the oil. The results indicate that consuming unstabilized fish oils as a source of n-3 fatty acids may entail exposure to potentially toxic products of lipid peroxidation.
尿丙二醛（MDA）是饮食和组织中脂质过氧化的指标，在食用来自药用级鱼肝油（CLO）且未添加抗氧化剂的n-3脂肪酸补充剂的成年人与食用含有十二烷基没食子酸酯和维生素E的n-3酸浓缩物的成年人中进行了测定。食用CLO的受试者尿丙二醛排泄立即增加，但摄入浓缩物的受试者在50天内保持不变。服用CLO的受试者丙二醛增加归因于油中的丙二醛。结果表明，食用不稳定的鱼油作为n-3脂肪酸来源可能会导致接触脂质过氧化的潜在有毒产物。
