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[鱼油和鱼肝油制剂中的脂肪酸组成及过氧化程度]

[Fatty acid composition and degree of peroxidation in fish oil and cod liver oil preparations].

作者信息

Luley C, Klein B, Hanisch M, Prellwitz W

机构信息

Abteilung für Klinische Chemie und Laboratoriumsmedizin, Kliniken der Johannes-Gutenberg-Universität, Mainz.

出版信息

Arzneimittelforschung. 1988 Dec;38(12):1783-6.

PMID:2854466
Abstract

Omega-3-fatty acids are increasingly used by the selfmedicating patient. Since fish oils in capsules are regarded as dietary food, there are neither official regulations in the Federal Republic of Germany concerning a minimum content of omega-3-fatty acids nor detailed rules for the limitation of autoxidation of these highly reactive substances. Both fatty acid composition and the degree of lipid peroxidation were measured in this study in 23 OTC fish oil preparations. The proportion of omega-3-fatty acids was in most fish oils about 30%; exceptions were the only ethyl ester among the preparations with 59% and the cod liver oils (13% to 22%). Regarding the peroxide value considerable differences were found: the lowest was 2 and the highest was 44.7. Since lipid peroxides and their degradation products are basically toxic, a limitation of the allowed degree of lipid peroxidation in fish oils is strongly recommended.

摘要

自我药疗的患者越来越多地使用ω-3脂肪酸。由于胶囊装的鱼油被视为膳食食品,在德意志联邦共和国既没有关于ω-3脂肪酸最低含量的官方规定,也没有针对这些高活性物质自氧化限制的详细规则。在本研究中,对23种非处方鱼油制剂的脂肪酸组成和脂质过氧化程度进行了测定。大多数鱼油中ω-3脂肪酸的比例约为30%;例外情况是制剂中唯一的乙酯含59%,以及鱼肝油(13%至22%)。关于过氧化值,发现有相当大的差异:最低为2,最高为44.7。由于脂质过氧化物及其降解产物基本上是有毒的,强烈建议限制鱼油中允许的脂质过氧化程度。

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