Yan Maria, Bustos Samyd S, Kuruoglu Doga, Ciudad Pedro, Forte Antonio J, Kim Esther A, Del Corral Gabriel, Manrique Oscar J
Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Center for Regenerative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Ann Transl Med. 2021 Apr;9(7):613. doi: 10.21037/atm-20-4523.
Transgender patients often desire to have biological children. However, their reproductive potential is often negatively impacted by gender affirming surgery (GAS) such as gender confirmation surgery (bottom surgery) and medical hormone therapy. Therefore, counselling patients on fertility preservation options before initiating gender-affirming treatments is prudent to avoid reducing their reproductive potential. A systematic review of English, Spanish, Chinese, French and Turkish languages from 2000 to December 23rd, 2019, using the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) guidelines, was conducted. The search strategy was designed and conducted by an experienced librarian with input from the study's principle investigator. Fifteen articles that report outcomes of fertility preservation options in transgenders were included. Eight articles described options for transgender women, six reported options for transgender men and one included both transgender women and transgender men. Semen cryopreservation and oocyte cryopreservation are the most common and available methods for fertility preservation in transgenders. Physician awareness of fertility preservation options in transgender patients is crucial to ensure informed discussions regarding reproductive options in the early phase of transition.
跨性别患者通常渴望生育亲生孩子。然而，他们的生殖潜力常常受到性别肯定手术（GAS）的负面影响，比如性别确认手术（下体手术）和药物激素治疗。因此，在开始性别肯定治疗之前，为患者提供关于生育力保存选择的咨询是明智的，以避免降低他们的生殖潜力。我们使用系统评价与荟萃分析方案优先报告条目（PRISMA-P）指南，对2000年至2019年12月23日期间的英文、西班牙文、中文、法文和土耳其文文献进行了系统评价。检索策略由一位经验丰富的图书馆员设计并实施，研究的主要研究者也提供了相关意见。纳入了15篇报告跨性别者生育力保存选择结果的文章。其中8篇描述了跨性别女性的选择，6篇报告了跨性别男性的选择，1篇同时涵盖了跨性别女性和跨性别男性。精液冷冻保存和卵母细胞冷冻保存是跨性别者最常见且可行的生育力保存方法。医生了解跨性别患者的生育力保存选择对于确保在过渡初期就生殖选择进行充分知情的讨论至关重要。
