Kanaev S V, Kholin A V, Gershanovich M L, Malinin A P, Semenov I I
Med Radiol (Mosk). 1988 Jul;33(7):40-6.
The results of therapy of 152 patients with stage III Hodgkin's disease (106--IIIA, 46--IIIB) were studied. The administration of 2-4 cycles of polychemotherapy (MOPP scheme including embichin, vincristine, procarbazine and prednisolone) followed by large field irradiation after a radical program in 2-4 weeks was envisaged in the therapeutic plan. Cox's multifactor regression analysis made it possible to determine the values of some indices for the outcome of disease. The main prognostic factors in chemo- and radiotherapy were a histological type and mediastinal lymph node involvement. The fact of the involvement of the mediastinal lymph nodes in a tumor process rather than a degree of their enlargement played a decisive role. Such prognostic factors as male sex and the age over 40 were regarded as unfavorable, however their role was not as important as that of a histological type and mediastinal lymph node involvement. The above program of chemo- and radiotherapy made it possible to reduce the effect of general symptoms and signs of "biological activity" of a process.
对152例III期霍奇金病患者（106例为IIIA期，46例为IIIB期）的治疗结果进行了研究。治疗方案设想在2 - 4周内进行根治性治疗后给予2 - 4周期的多药化疗（MOPP方案，包括氮芥、长春新碱、丙卡巴肼和泼尼松龙），随后进行大野照射。Cox多因素回归分析使得确定疾病预后的一些指标值成为可能。化疗和放疗中的主要预后因素是组织学类型和纵隔淋巴结受累情况。纵隔淋巴结在肿瘤过程中的受累事实而非其肿大程度起决定性作用。男性性别和40岁以上等预后因素被视为不利因素，但其作用不如组织学类型和纵隔淋巴结受累情况重要。上述化疗和放疗方案能够减轻疾病“生物活性”的一般症状和体征。
