Graduate School of Engineering, Muroran Institute of Technology, Muroran, Japan.
Department of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Chirality. 2021 Aug;33(8):454-464. doi: 10.1002/chir.23319. Epub 2021 May 13.
New two catalysts component system comprising of a primary β-amino silyl ethers as an organocatalyst and N-protected amino acids as a co-catalyst put together worked as an efficient organocatalyst system in the hetero Diels-Alder reaction of isatins with enones affording the chiral spirooxindole-tetrahydropyranones in good chemical yields and stereoselectivities (up to 94%, up to dr 78:22., up to 85% ee).
新型的双催化剂成分体系由伯β-氨硅醚作为有机催化剂和 N-保护氨基酸作为共催化剂组成，在异色满酮与烯酮的杂 Diels-Alder 反应中表现出高效的有机催化体系，以良好的化学收率和立体选择性（高达 94%，dr 高达 78:22，ee 高达 85%）得到手性螺环氧化吲哚-四氢吡喃酮。
