特发性血小板减少性紫癜的存在与急性 ST 段抬高型心肌梗死的发生率降低相关。
The presence of idiopathic thrombocytopenic purpura correlates with lower rate of acute ST-elevation myocardial infarction.
机构信息
College of Medicine Phoenix, University of Arizona, AZ 85004, USA.
CareMore, Tucson, AZ 85718, USA.
出版信息
Future Cardiol. 2021 Nov;17(8):1327-1333. doi: 10.2217/fca-2020-0183. Epub 2021 May 14.
Platelets are important in the pathogenesis of myocardial infarction (MI). We hypothesize that patients with acquired thrombocytopenia such as idiopathic thrombocytopenic purpura (ITP) may have lower MI rate. The Nationwide Inpatient Sample was used for this study. We analyzed the correlation between ST-elevation MI (STEMI) and ITP utilizing ICD-9 codes. STEMI rate was lower in patients with ITP. We found that, in 2002, STEMI occurred in 0.64% of patients with ITP versus 0.89 (p < 0.007) and for 2011 0.30 versus 0.48 (p < 0.005). After adjusting for tobacco use, diabetes, hypertension, hyperlipidemia, gender and age, STEMI rate remained lower in ITP patients. ITP appears to be associated with lower STEMI rate suggesting low platelet count may exert protective effect from STEMI.
血小板在心肌梗死（MI）的发病机制中起重要作用。我们假设患有特发性血小板减少性紫癜（ITP）等获得性血小板减少症的患者可能会有较低的 MI 发生率。本研究使用了全国住院患者样本。我们利用 ICD-9 代码分析了 ST 段抬高型心肌梗死（STEMI）与 ITP 之间的相关性。ITP 患者的 STEMI 发生率较低。我们发现，在 2002 年，ITP 患者的 STEMI 发生率为 0.64%，而 0.89%（p<0.007），2011 年为 0.30%，而 0.48%（p<0.005）。调整吸烟、糖尿病、高血压、高血脂、性别和年龄后，ITP 患者的 STEMI 发生率仍然较低。ITP 似乎与较低的 STEMI 发生率相关，这表明低血小板计数可能对 STEMI 具有保护作用。
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