Faculty of Engineering, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castellon, Spain.
Biomater Sci. 2021 Aug 21;9(16):5397-5406. doi: 10.1039/d1bm00430a. Epub 2021 May 14.
3D printable materials based on polymeric ionic liquids (PILs) capable of controlling the synthesis and stabilisation of silver nanoparticles (AgNPs) and their synergistic antimicrobial activity are reported. The interaction of the ionic liquid moieties with the silver precursor enabled the controlled in situ formation and stabilisation of AgNPs via extended UV photoreduction after the printing process, thus demonstrating an effective decoupling of the device manufacturing from the on-demand generation of nanomaterials, which avoids the potential aging of the nanomaterials through oxidation. The printed devices showed a multi-functional and tuneable microbicidal activity against Gram positive (B. subtilis) and Gram negative (E. coli) bacteria and against the mould Aspergillus niger. While the polymeric material alone was found to be bacteriostatic, the AgNPs conferred bactericidal properties to the material. Combining PIL-based materials with functionalities, such as in situ and photoactivated on-demand fabricated antimicrobial AgNPs, provides a synergistic functionality that could be harnessed for a variety of applications, especially when coupled to the freedom of design inherent to additive manufacturing techniques.
基于聚合离子液体（PIL）的 3D 可打印材料能够控制银纳米粒子（AgNPs）的合成和稳定，并具有协同抗菌活性。离子液体部分与银前体的相互作用能够在打印后通过扩展的紫外光还原来控制 AgNPs 的原位形成和稳定，从而有效地将器件制造与按需生成纳米材料解耦，避免了纳米材料通过氧化而潜在老化。所打印的器件对革兰氏阳性（枯草芽孢杆菌）和革兰氏阴性（大肠杆菌）细菌以及霉菌黑曲霉表现出多功能和可调的杀菌活性。虽然单独的聚合物材料被发现具有抑菌作用，但 AgNPs 赋予了材料杀菌性能。将基于 PIL 的材料与功能相结合，例如原位和光激活按需制造的抗菌 AgNPs，提供了一种协同功能，可以应用于各种应用，特别是与增材制造技术固有的设计自由度相结合时。
