Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, 300052, PR China.
Department of Cardiology, Tianjin Medical University General Hospital, Tianjin, 300052, PR China.
Biomark Med. 2021 Jun;15(8):577-584. doi: 10.2217/bmm-2020-0305. Epub 2021 May 14.
To determine the association between mean platelet volume (MPV) and hypertension subtypes. 44,281 Chinese individuals were enrolled in this cross-sectional study. The mean blood pressure decreased with increasing MPV in females (p = 0.001) and increased MPV seemed to be a potential protective factor for isolated diastolic hypertension in models 1 and 2. The OR (CI) was 0.878 (0.789-0.976) for model 1 and 0.880 (0.789-0.981) for model 2 in males and 0.646 (0.495-0.841) for model 1 and 0.657 (0.503-0.858) for model 2 in females, when MPV was analyzed as a categorical variable. The OR (CI) was 0.947 (0.911-0.985) for Model 1 and 0.947 (0.910-0.985) for Model 2 in males, and 0.886 (0.807-0.973) for Model 1 and 0.892 (0.813-0.978) for Model 2 in females when MPV was analyzed as a continuous variable. However, the statistical difference of OR disappeared when we added blood-related covariates in Model 3. No obvious association exists between MPV and hypertension subtypes. Other blood parameters might have a greater impact on hypertension subtypes.
探讨平均血小板体积（MPV）与高血压亚型之间的关系。
本横断面研究纳入了 44281 名中国个体。结果：女性的平均血压随 MPV 的增加而降低（p = 0.001），而在模型 1 和模型 2 中，MPV 升高似乎是单纯舒张期高血压的潜在保护因素。在男性中，MPV 作为分类变量进行分析时，模型 1 和模型 2 的 OR（CI）分别为 0.878（0.789-0.976）和 0.880（0.789-0.981），而在女性中，模型 1 和模型 2 的 OR（CI）分别为 0.646（0.495-0.841）和 0.657（0.503-0.858）。MPV 作为连续变量进行分析时，在男性中，模型 1 和模型 2 的 OR（CI）分别为 0.947（0.911-0.985）和 0.947（0.910-0.985），在女性中，模型 1 和模型 2 的 OR（CI）分别为 0.886（0.807-0.973）和 0.892（0.813-0.978）。然而，当我们在模型 3 中加入与血液相关的协变量时，OR 的统计学差异消失了。
MPV 与高血压亚型之间无明显相关性。其他血液参数可能对高血压亚型有更大的影响。
