Shakeri Shamsi Fateme, Taheri Soodejani Moslem
Center for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Int J Hypertens. 2024 Feb 13;2024:3705771. doi: 10.1155/2024/3705771. eCollection 2024.
Hypertension is one of the most important diseases worldwide. In this study, we aim to demonstrate the relationship between platelet indices and hypertension.
We studied 9448 people in the age range of 30 to 70 years. We assessed their hypertension status, platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), smoking, cardiovascular disease history, diabetes status, body mass index, and creatinine levels. Hypertension status was assessed qualitatively. All platelet indices were categorized by quartiles. We then used logistic regression to predict the relationship between these indices and hypertension.
PDW index and hypertension had a statistically significant relationship in the second quartile (16.2 fL < PDW ≤ 16.7 fL) in 30 to 40 years old (AOR: 0.225, 95% CI: 0.063-0.806), in the fourth quartile in 50 to 60 years old (AOR = 1.532, 95% CI: 1.048-2.238), and in all the quartiles of the age range of over 60 years. PLT index had a positive relationship (AOR = 3.147, 0.95% CI: 1.163-8.516) in 30 to 40 years old in the fourth quartile vs. the first quartile. A positive relationship was obtained in the third and fourth quartiles of PLT and the age range of 40 to 50 years, respectively (AOR = 2.063, 0.95% CI: 1.162-3.662) and (AOR = 2.204, 0.95% CI: 1.220-3.981).
According to the results of this study, some platelet indices could be correlated with hypertension, so we may be able to reduce the burden of this disease.
高血压是全球最重要的疾病之一。在本研究中，我们旨在证明血小板指标与高血压之间的关系。
我们研究了9448名年龄在30至70岁之间的人。我们评估了他们的高血压状况、血小板计数（PLT）、平均血小板体积（MPV）、血小板分布宽度（PDW）、吸烟情况、心血管疾病史、糖尿病状况、体重指数和肌酐水平。高血压状况采用定性评估。所有血小板指标按四分位数进行分类。然后我们使用逻辑回归来预测这些指标与高血压之间的关系。
在30至40岁人群的第二个四分位数（16.2 fL＜PDW≤16.7 fL）、50至60岁人群的第四个四分位数以及60岁以上年龄范围的所有四分位数中，PDW指标与高血压存在统计学显著关系（比值比：0.225，95%置信区间：0.063 - 0.806）、（比值比 = 1.532，95%置信区间：1.048 - 2.238）。在30至40岁人群中，第四个四分位数与第一个四分位数相比，PLT指标呈正相关（比值比 = 3.147，95%置信区间：1.163 - 8.516）。在40至50岁年龄范围中，PLT的第三个和第四个四分位数分别呈正相关（比值比 = 2.063，95%置信区间：1.162 - 3.662）和（比值比 = 2.204，95%置信区间：1.220 - 3.981）。
根据本研究结果，一些血小板指标可能与高血压相关，因此我们或许能够减轻这种疾病的负担。
