Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, India.
Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Kandi, India.
Neurol Sci. 2021 Aug;42(8):3101-3119. doi: 10.1007/s10072-021-05303-1. Epub 2021 May 14.
Neurodegenerative disorders like Alzheimer's, Parkinson's, and associated dementia typically originate with altered protein folding and aggregation of their β structures in the neurons. This self-aggregation leads to glial activation in the brain, causing neuroinflammation and leads to neuronal death. According to statistics provided by WHO, there are around 50 million people with dementia worldwide and every year, 10 million more cases are projected to increase. Also, around 5-8 percentage of people who are aged above 60 globally has dementia or associated disorders. Over 82 million in 2030 and 152 in 2050 are expected to have dementia. Most of these patients fall into low-middle-income countries which makes it even more essential to find an affordable and effective treatment method. Polyphenols of different origin are studied for their potential role as anti-neuro-inflammatory molecules. This review would summarize recent advances in three widely researched dietary polyphenols projected as potential therapeutic agents for disorders like Alzheimer's, Parkinson's, etc. They are Resveratrol, Catechins, and Tannins. The review would discuss the recent advances and challenges in using these polyphenols using specific examples as potential therapeutic agents against neuroinflammation associated disorders. An abstract of neuroinflammation-associated events and the effects by selected polyphenols.
神经退行性疾病，如阿尔茨海默病、帕金森病和相关痴呆症，通常起源于神经元中β结构的蛋白质折叠和聚集的改变。这种自聚集导致大脑中的神经胶质细胞激活，引起神经炎症，导致神经元死亡。根据世界卫生组织提供的统计数据，全球约有 5000 万人患有痴呆症，每年预计还会增加 1000 万病例。此外，全球约有 5-8%的 60 岁以上人群患有痴呆症或相关疾病。到 2030 年，预计将有 8200 万人，到 2050 年，预计将有 1.52 亿人患有痴呆症。这些患者大多数来自中低收入国家，因此找到一种负担得起且有效的治疗方法就显得尤为重要。不同来源的多酚被研究其作为抗神经炎症分子的潜在作用。这篇综述将总结三种广泛研究的膳食多酚作为治疗阿尔茨海默病、帕金森病等疾病的潜在治疗剂的最新进展。它们是白藜芦醇、儿茶素和单宁。综述将讨论使用这些多酚作为治疗与神经炎症相关疾病的潜在治疗剂的最新进展和挑战，并通过具体实例进行讨论。概述与神经炎症相关的事件以及选定多酚的作用。
