Wiechers D O
Muscle Nerve. 1988 Apr;11(4):356-64. doi: 10.1002/mus.880110412.
A late onset of slowly progressive muscle weakness 30-40 years after acute polio is well known. Previous studies by the author and others have demonstrated transmission abnormalities within the reinnervated motor unit. These transmission abnormalities shown by motor unit action potential (MUAP) instability in size and shape with repetitive discharges occurs in postpolio patients who are and who are not complaining of progressive muscle weakness. Although some reinnervated MUAPs do seem to stabilize their neuromuscular transmission with time in mildly affected muscles, the question arises as to whether or not some MUAPs ever stabilize after polio. Two cases of acute polio personally followed by the author, one over a 9 1/2 year period, are presented. In both cases, in muscles where there are more deinnervated muscle fibers than could possibly be reinnervated, the MUAPs have remained unstable. New concepts of function in the reinnervated motor unit following polio are presented.
急性脊髓灰质炎后30至40年出现迟发性、缓慢进展的肌肉无力是众所周知的。作者和其他人之前的研究已经证明了再支配运动单位内的传导异常。运动单位动作电位（MUAP）在大小和形状上的不稳定性以及重复性放电所显示的这些传导异常，在有和没有进行性肌肉无力主诉的脊髓灰质炎后患者中均会出现。尽管一些再支配的MUAPs在轻度受影响的肌肉中似乎会随着时间推移稳定其神经肌肉传导，但问题在于脊髓灰质炎后一些MUAPs是否曾经稳定过。本文介绍了作者亲自随访的2例急性脊髓灰质炎病例，其中1例随访了9年半。在这两个病例中，在失神经支配的肌纤维数量超过可能再支配数量的肌肉中，MUAPs一直不稳定。本文还提出了脊髓灰质炎后再支配运动单位功能的新概念。
