Zhang Man-Yu, Li Tong, Qian Xiao-Yan, Liu Hui, Zhao Qian-Nan, Liu Cai-Cai, Wang Yong, Williams John P, An Jian-Xiong
School of Anesthesiology, Weifang Medical University, Weifang City, Shandong Province, China; Department of Anesthesiology, Pain and Sleep Medicine, Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing, China.
Department of Pain Management, Lanzhou Maternity and Child Healthcare Hospital, Lanzhou, China.
Pain Physician. 2021 May;24(3):E367-E375.
Numerous therapies have been developed for the treatment of chronic pelvic pain (CPP). Oxygen-ozone therapy is a new method for the treatment of CPP.
This article evaluated the feasibility of ultrasound-guided peritoneal perfusion with ozone in patients with CPP.
This is a bicenter retrospective study.
The study was conducted at 2 pain centers of a university hospital.
The medical records of patients with CPP (n = 60) from March 2016 until October 2018 were collected and reviewed. Group A contained 19 patients who were treated with a 1500 mcg dose of ozonated water (10 mcg/mL concentration and 150 mL volume), group B contained 23 patients using the same dose of ozonated water but a 15 mcg/mL concentration and 100 mL volume. Group C included 18 patients using a similar ozone dose but delivered in an oxygen-ozone mixture (15 mcg/mL concentration and 100 mL volume oxygen-ozone mixture). Visual Analog Scale (VAS) scores for pain of the 3 groups were compared at pretreatment, posttreatment, 1, 3, and 6 months posttreatment. The injection pain was evaluated using a 4-point verbal rating scale. Quality of life (QoL), anxiety, and depression were assessed at pretreatment and at 6 months posttreatment.
The VAS scores of the 3 groups decreased over time following treatment. Group A showed much higher pain scores compared with groups B and C at 1, 3, and 6 months posttreatment. However, the injection pain for groups B and C was higher than group A, but there was no difference seen between group B and C. At 6 months posttreatment, the QoL for all patients improved compared with pretreatment, whereas the anxiety and depression did not demonstrate differences.
The main limitations of this study are the retrospective study design, limited case number, and short follow-up period.
Ultrasound-guided peritoneal perfusion with ozone is a feasible therapy for patients with CPP.
已研发出多种治疗慢性盆腔疼痛（CPP）的疗法。臭氧疗法是一种治疗CPP的新方法。
本文评估超声引导下臭氧腹腔灌注治疗CPP患者的可行性。
这是一项双中心回顾性研究。
该研究在一家大学医院的2个疼痛中心进行。
收集并回顾了2016年3月至2018年10月期间CPP患者（n = 60）的病历。A组包含19例接受1500微克臭氧水剂量治疗的患者（浓度为10微克/毫升，体积为150毫升），B组包含23例使用相同剂量臭氧水但浓度为15微克/毫升且体积为100毫升的患者。C组包括18例使用类似臭氧剂量但以氧 - 臭氧混合物形式给药的患者（浓度为15微克/毫升，体积为100毫升氧 - 臭氧混合物）。比较3组患者治疗前、治疗后、治疗后1个月、3个月和6个月时疼痛的视觉模拟评分（VAS）。使用4分语言评定量表评估注射疼痛。在治疗前和治疗后6个月评估生活质量（QoL）、焦虑和抑郁情况。
治疗后3组的VAS评分随时间下降。治疗后1个月、3个月和6个月时，A组的疼痛评分显著高于B组和C组。然而，B组和C组的注射疼痛高于A组，但B组和C组之间无差异。治疗后6个月时，所有患者的QoL较治疗前有所改善，而焦虑和抑郁情况无差异。
本研究的主要局限性在于回顾性研究设计、病例数有限以及随访期较短。
超声引导下臭氧腹腔灌注对CPP患者是一种可行的治疗方法。
