State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, P. R. China.
J Agric Food Chem. 2021 May 26;69(20):5575-5582. doi: 10.1021/acs.jafc.0c06612. Epub 2021 May 14.
To find efficient and broad-spectrum viral agents, a series of purine nucleoside derivatives containing sulfa ethylamine moieties was designed and synthesized, and their antiviral activities against tobacco mosaic virus (TMV), cucumber mosaic virus (CMV), and potato virus Y (PVY) were evaluated. Some target compounds displayed good antiviral activities. Among them, compound showed excellent protective activity against CMV and PVY with 50% effective concentration values (EC) of 137 and 209 μg/mL, respectively, which were better than that of the control agent ningnanmycin (508 and 431 μg/mL). Moreover, the EC value of compound for the inactivating activity against TMV was 48 μg/mL, which was better than that of ningnanmycin (88 μg/mL). In addition, compound not only destroyed the structure of the TMV virus but also had a good interaction with the coat protein of the TMV virus. Therefore, compound may further destroy the structure of the virus by binding to the coat protein of the TMV virus, thereby weakening the infectivity of the virus.
为了寻找高效广谱的病毒制剂，设计并合成了一系列含磺乙基胺结构的嘌呤核苷衍生物，并评价了它们对烟草花叶病毒（TMV）、黄瓜花叶病毒（CMV）和马铃薯 Y 病毒（PVY）的抗病毒活性。部分目标化合物表现出良好的抗病毒活性。其中，化合物 对 CMV 和 PVY 显示出优异的保护活性，其对 CMV 和 PVY 的 50%有效浓度（EC）值分别为 137 和 209μg/mL，优于对照药剂宁南霉素（508 和 431μg/mL）。此外，化合物 对 TMV 的灭活活性的 EC 值为 48μg/mL，优于宁南霉素（88μg/mL）。此外，化合物 不仅破坏了 TMV 病毒的结构，而且与 TMV 病毒的外壳蛋白具有良好的相互作用。因此，化合物 可能通过与 TMV 病毒的外壳蛋白结合进一步破坏病毒的结构，从而减弱病毒的感染力。
