National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Guizhou Rice Research Institute, Guizhou Academy of Agricultural Sciences, Guiyang 550025, China.
Int J Mol Sci. 2023 Jun 28;24(13):10807. doi: 10.3390/ijms241310807.
Benzoxazole and benzothiazole have a broad spectrum of agricultural biological activities, such as antibacterial, antiviral, and herbicidal activities, which are important fused heterocyclic scaffold structures in agrochemical discovery. In recent years, great progress has been made in the research of benzoxazoles and benzothiazoles, especially in the development of herbicides and insecticides. With the widespread use of benzoxazoles and benzothiazoles, there may be more new products containing benzoxazoles and benzothiazoles in the future. We systematically reviewed the application of benzoxazoles and benzothiazoles in discovering new agrochemicals in the past two decades and summarized the antibacterial, fungicidal, antiviral, herbicidal, and insecticidal activities of the active compounds. We also discussed the structural-activity relationship and mechanism of the active compounds. This work aims to provide inspiration and ideas for the discovery of new agrochemicals based on benzoxazole and benzothiazole.
苯并恶唑和苯并噻唑具有广泛的农业生物活性，如抗菌、抗病毒和除草活性，是农用化学品发现中重要的稠合杂环骨架结构。近年来，苯并恶唑和苯并噻唑的研究取得了很大进展，特别是在除草剂和杀虫剂的开发方面。随着苯并恶唑和苯并噻唑的广泛使用，未来可能会有更多含有苯并恶唑和苯并噻唑的新产品。我们系统地综述了过去 20 年中苯并恶唑和苯并噻唑在发现新农用化学品方面的应用，并总结了活性化合物的抗菌、杀菌、抗病毒、除草和杀虫活性。我们还讨论了活性化合物的构效关系和作用机制。这项工作旨在为基于苯并恶唑和苯并噻唑的新农用化学品的发现提供启示和思路。
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