缺铁饿死细菌：一种分散细菌生物膜的潜在策略。
Starving Bacteria of Iron: A Potential Strategy to Disperse Bacterial Biofilms.
机构信息
Chemistry Department, Institute for Drug Discovery, Purdue University, West Lafayette, Indiana 47907, United States.
Purdue Institute for Inflammation, Immunology, and Infectious Diseases, Purdue University, West Lafayette, Indiana 47907, United States.
出版信息
J Med Chem. 2021 Jun 10;64(11):7272-7274. doi: 10.1021/acs.jmedchem.1c00749. Epub 2021 May 14.
Abstract
Halogenated phenazines (HPs) are potent antimicrobial agents. A newly developed halogenated phenazine, HP-, displays remarkable minimum inhibitory concentration (MIC) of 0.08 μM against methicillin-resistant , MRSA. HP- eradicates preformed biofilm via iron starvation, is nontoxic to mammalian cell lines and is efficacious in wound infection models.
摘要
卤代吩嗪（HPs）是有效的抗菌剂。一种新开发的卤代吩嗪，HP-，对耐甲氧西林金黄色葡萄球菌（MRSA）显示出显著的最低抑菌浓度（MIC），为 0.08 μM。HP 通过铁饥饿根除已形成的生物膜，对哺乳动物细胞系无毒，在伤口感染模型中有效。
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