白细胞介素-1 在肿瘤进展、治疗和预防中的作用。

Interleukin-1 in tumor progression, therapy, and prevention.

机构信息

Humanitas Research Hospital-IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy; Humanitas University, Department of Biomedical Sciences, Via Rita Levi Montalcini 4, 20090 Pieve Emanuele, Milan, Italy; The William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

出版信息

Cancer Cell. 2021 Aug 9;39(8):1023-1027. doi: 10.1016/j.ccell.2021.04.011. Epub 2021 May 13.

DOI:10.1016/j.ccell.2021.04.011

PMID:33989512

Abstract

Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important role in tumor progression. Based on preclinical models and human genetic associations, we surmise that targeting IL-1 should be considered in treating selected human tumors as well as in a prevention and/or interception setting.

摘要

白细胞介素-1（IL-1）是炎症的关键协调因子，在肿瘤进展中起着重要作用。基于临床前模型和人类遗传关联，我们推测在治疗选定的人类肿瘤以及在预防和/或干预设置中，靶向 IL-1 应该被考虑。