Oniani T N, Gvetadze L B, Mandzhavidze Sh D
Neirofiziologiia. 1988;20(2):160-7.
Dynamics of neuronal activity of the posterior hypothalamus in the sleep-wakefulness cycle was studied in free moving cats using mobile metal microelectrodes. Computer analysis and statistical treatment of the data have shown that the majority of neurons (89.3%) in the above-mentioned area discharge with high frequency during active wakefulness and emotional stage of paradoxical sleep; the frequency of discharges decreases during passive wakefulness and nonemotional stage of paradoxical sleep and is the lowest in the slow wave sleep though it has been higher than at the other states. Comparatively small number of neurons (3.6%) show opposite dynamics of the activity. They fire more intensely during slow wave sleep and the frequency of discharges decreases during active wakefulness and paradoxical sleep. In posterior hypothalamus some neurons (7.1%) are found which fire intensely during active wakefulness as compared with slow wave sleep and paradoxical sleep. The neurophysiological mechanisms for regulation of the sleep-wakefulness cycle and the involvement of posterior hypothalamus in this process are discussed.
使用可移动金属微电极，对自由活动的猫在睡眠-觉醒周期中下丘脑后部神经元活动的动态变化进行了研究。对数据的计算机分析和统计处理表明，上述区域中的大多数神经元（89.3%）在主动觉醒和异相睡眠的情感阶段高频放电；在被动觉醒和异相睡眠的非情感阶段放电频率降低，在慢波睡眠中最低，尽管仍高于其他状态。相对少数的神经元（3.6%）表现出相反的活动动态。它们在慢波睡眠期间放电更强烈，而在主动觉醒和异相睡眠期间放电频率降低。在下丘脑后部发现一些神经元（7.1%），与慢波睡眠和异相睡眠相比，它们在主动觉醒期间放电强烈。讨论了睡眠-觉醒周期调节的神经生理机制以及下丘脑后部在这一过程中的参与情况。
