Oniani T N, Gvetadze L B, Mandzhavidze Sh D
Neirofiziologiia. 1984;16(5):678-90.
Dynamics of neuronal activity of the mesencephalic reticular nuclei (n. cuneiformis, n. parabrachialis) in the sleep-wakefulness cycle was studied in free moving rats using mobile metallic microelectrodes. Computer analysis and statistical treatment of data have shown that the majority of neurons in the above-mentioned reticular nuclei of the mesencephalon (76% and 66%, respectively) generate with high frequencies during active wakefulness and emotional stage of paradoxical sleep; the frequency of discharges is less during passive wakefulness and nonemotional stage of paradoxical sleep, while in the slow-wave sleep they exhibit the least activity. Comparatively small number of neurons (24%, 15%) show inverse dynamics of activity. They fire more intensively during slow wave sleep and the frequency of discharges decreases during active wakefulness and emotional stage of paradoxical sleep. During quiet wakefulness and nonemotional stage of paradoxical sleep the neuronal activity attains the level observed in a slow-wave sleep. In n. parabrachialis some neurons are found which fire intensively during active wakefulness, the frequency of their discharges decreases in passive wakefulness and slow-wave sleep and is the least in paradoxical sleep. The similarity and difference of the neurophysiological mechanisms of phases and stages of the sleep-wakefulness cycle are discussed.
使用可移动金属微电极，对自由活动大鼠睡眠-觉醒周期中脑桥网状核（楔形核、臂旁核）神经元活动的动态变化进行了研究。数据的计算机分析和统计处理表明，中脑上述网状核中的大多数神经元（分别为76%和66%）在主动觉醒和异相睡眠的情感阶段高频发放；在被动觉醒和异相睡眠的非情感阶段发放频率较低，而在慢波睡眠中它们的活动最少。相对少数的神经元（24%、15%）表现出相反的活动动态。它们在慢波睡眠期间发放更强烈，而在主动觉醒和异相睡眠的情感阶段发放频率降低。在安静觉醒和异相睡眠的非情感阶段，神经元活动达到在慢波睡眠中观察到的水平。在臂旁核中发现一些神经元在主动觉醒期间强烈发放，其发放频率在被动觉醒和慢波睡眠中降低，在异相睡眠中最低。讨论了睡眠-觉醒周期各阶段神经生理机制的异同。
