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胰岛素治疗:宝贵的遗产及其未来展望。

Insulin therapy; a valuable legacy and its future perspective.

机构信息

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan..

出版信息

Int J Biol Macromol. 2021 Jun 30;181:1224-1230. doi: 10.1016/j.ijbiomac.2021.05.052. Epub 2021 May 12.

Abstract

Proteins and peptides are widely used in various areas including pharmaceutical, health, food, textile and biofuel industries. At present, pharmaceutical proteins and peptides have attracted the attention of many researchers. These types of drugs are superior to chemical drugs in many ways so that every year the number of drugs with a protein or peptide moiety is increasing. Due to high performance and low side effects, the demand for these drugs has increased year by year. The beginning of the protein and peptide drug industry dates back to 1982 with the introduction of the protein hormone insulin into the field of treatment. From this year onwards, a new number of protein and peptide drugs have entered the field of treatment every year. In this article, we focus on human therapeutic insulin. First, the history of the hormone will be introduced, then-current methods for insulin therapy will be discussed and finally, the treatments by this hormone in the future will be pointed. Reading this article would be very helpful for nano researchers, biochemists, organic chemists, material scientists and other people who are interested in soft and hard matters interfaces.

摘要

蛋白质和肽广泛应用于制药、保健、食品、纺织和生物燃料等各个领域。目前,蛋白质和肽类药物已经引起了许多研究人员的关注。这些类型的药物在许多方面优于化学药物,以至于每年具有蛋白质或肽部分的药物数量都在增加。由于其高性能和低副作用,这些药物的需求逐年增加。蛋白质和肽类药物产业的开端可以追溯到 1982 年,当时蛋白质激素胰岛素被引入治疗领域。从这一年起,每年都有新的蛋白质和肽类药物进入治疗领域。在本文中,我们专注于人类治疗性胰岛素。首先,将介绍该激素的历史,然后讨论当前的胰岛素治疗方法,最后指出该激素在未来的治疗应用。阅读本文将对纳米研究人员、生物化学家、有机化学家、材料科学家和其他对软物质和硬物质界面感兴趣的人非常有帮助。

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