GSK3 在癌症代谢途径紊乱中的作用。

The role of GSK3 in metabolic pathway perturbations in cancer.

机构信息

Lady Davis Institute for Medical Research, 3755 Chemin de la Côte-Sainte-Catherine, Montréal, QC H3T 1E2, Canada; Gerald Bronfman Department of Oncology, McGill University, 5100 Maisonneuve Blvd West, Montréal, QC H4A 3T2, Canada; Department of Medicine, Division of Experimental Medicine, McGill University, 1001 Décarie Blvd, Montréal, QC H4A 3J1, Canada.

出版信息

Biochim Biophys Acta Mol Cell Res. 2021 Jul;1868(8):119059. doi: 10.1016/j.bbamcr.2021.119059. Epub 2021 May 12.

DOI:10.1016/j.bbamcr.2021.119059

PMID:33989699

Abstract

Malignant transformation and tumor progression are accompanied by significant perturbations in metabolic programs. As such, cancer cells support high ATP turnover to construct the building blocks needed to fuel neoplastic growth. The coordination of metabolic networks in malignant cells is dependent on the collaboration with cellular signaling pathways. Glycogen synthase kinase 3 (GSK3) lies at the convergence of several signaling axes, including the PI3K/AKT/mTOR, AMPK, and Wnt pathways, which influence cancer initiation, progression and therapeutic responses. Accordingly, GSK3 modulates metabolic processes, including protein and lipid synthesis, glucose and mitochondrial metabolism, as well as autophagy. In this review, we highlight current knowledge of the role of GSK3 in metabolic perturbations in cancer.

摘要

恶性转化和肿瘤进展伴随着代谢程序的显著改变。因此，癌细胞支持高 ATP 周转率，以构建支持肿瘤生长所需的构建块。恶性细胞中代谢网络的协调依赖于与细胞信号通路的协作。糖原合酶激酶 3 (GSK3) 位于几个信号轴的交汇点，包括 PI3K/AKT/mTOR、AMPK 和 Wnt 途径，这些途径影响癌症的发生、进展和治疗反应。因此，GSK3 调节代谢过程，包括蛋白质和脂质合成、葡萄糖和线粒体代谢以及自噬。在这篇综述中，我们强调了 GSK3 在癌症代谢紊乱中的作用的最新知识。