School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan, Malaysia.
School of Pharmacy, University of Queensland, 20 Cornwall Street, Woolloongabba, QLD 4102, Australia.
Pharmacol Res. 2021 Jul;169:105666. doi: 10.1016/j.phrs.2021.105666. Epub 2021 May 12.
Benzyl isothiocyanate (BITC) is one of the common isothiocyanates found in cruciferous vegetables such as broccoli, cabbage or watercress. Preclinical studies report of its effectiveness in the prevention and treatment against several cancers. This review aims to report and discuss findings on anticancer activities of BITC and its modes of action against 14 types of cancer. A literature search was conducted using the keywords "BITC" and "anticancer" from PubMed, Google Scholar and CINAHL Plus to obtain relevant research articles. This review highlights the anticancer efficacy of BITC through modulation of various signaling pathways involved in apoptosis, cell proliferation, cell cycle arrest, metastasis, angiogenesis, autophagy and the effects of BITC in combination with other drugs. With the available pharmacology evidence, we conclude that further studies are needed to validate its effectiveness in humans for further development and translation into prophylaxis or therapy by promoting optimal therapeutic effects and minimizing toxicity in cancer treatment.
苄基异硫氰酸酯（BITC）是十字花科蔬菜（如西兰花、卷心菜或水田芥）中常见的异硫氰酸酯之一。临床前研究报告称，它在预防和治疗多种癌症方面具有有效性。本综述旨在报告和讨论 BITC 的抗癌活性及其针对 14 种癌症的作用机制。使用关键词“BITC”和“抗癌”，通过 PubMed、Google Scholar 和 CINAHL Plus 进行文献检索，以获取相关的研究文章。本综述强调了 BITC 通过调节涉及细胞凋亡、细胞增殖、细胞周期停滞、转移、血管生成、自噬的各种信号通路的抗癌功效，以及 BITC 与其他药物联合使用的效果。根据现有的药理学证据，我们得出结论，需要进一步研究来验证其在人类中的有效性，以便进一步开发并通过促进最佳治疗效果和最小化癌症治疗中的毒性将其转化为预防或治疗。
