Health Science Graduate Program, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Laboratory of Oral Histopathology, School of Health Sciences, University of Brasília, Brasília, DF, Brazil.
Crit Rev Oncol Hematol. 2021 Jun;162:103349. doi: 10.1016/j.critrevonc.2021.103349. Epub 2021 May 11.
To evaluate the effectiveness of photobiomodulation therapy (PBMT) in the prevention and treatment of radiation dermatitis (RD).
A systematic review was conducted using seven databases and the gray literature. We performed a meta-analysis to summarize the effect sizes of response rates (RRs).
We included seven clinical trials. Breast cancer patients receiving PBMT developed more grade 1 RD than the control group (RR 1.55, 95 % CI 1.14-2.10, I = 51 %). PBMT appears to prevent RD grade 2 (RR 0.33, 95 % CI 0.09-1.23, I = 85 %) and RD grade 3 (RR 0.21, 95 % CI 0.05-0.94, I = 0%) with very low certainty of evidence.
There is very low certainty of evidence that PBMT was effective in the prevention of RD. However, PBMT showed a significant effect to prevent grade 3 RD in breast cancer patients. Thus, further randomized clinical trials are required to confirm the promising effect of PBMT in RD.
评估光生物调节疗法（PBMT）在预防和治疗放射性皮炎（RD）中的有效性。
使用七个数据库和灰色文献进行系统评价。我们进行了荟萃分析以总结反应率（RR）的效果大小。
我们纳入了 7 项临床试验。接受 PBMT 的乳腺癌患者比对照组更易发生 1 级 RD（RR 1.55，95%CI 1.14-2.10，I²=51%）。PBMT 似乎可预防 2 级 RD（RR 0.33，95%CI 0.09-1.23，I²=85%）和 3 级 RD（RR 0.21，95%CI 0.05-0.94，I²=0%），但证据确定性极低。
低确定性证据表明 PBMT 对预防 RD 有效。然而，PBMT 对预防乳腺癌患者 3 级 RD 有显著效果。因此，需要进一步的随机临床试验来证实 PBMT 在 RD 中的有前途的效果。
