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[1例富血管性脑膜瘤:术前放疗的效果]

[A case of hypervascular meningioma: the effect of preoperative irradiation].

作者信息

Takahashi J, Makita Y, Nabeshima S, Tei T, Keyaki A, Miyamoto Y

机构信息

Department of Neurosurgery, Tenri Hospital, Nara, Japan.

出版信息

No Shinkei Geka. 1988;16(5 Suppl):597-601.

PMID:3399015
Abstract

A 30-year-old, right handed male was admitted with headache and mild right-sided motor weakness of one year's duration. A CT scan revealed a mass over the left frontal convexity. A cerebral angiogram showed a huge, hypervascular tumor which was fed by bilateral external carotid and left internal carotid arteries. Because of its size and location, a surgical intervention was considered contraindicated at that time. Instead he was initially irradiated 52 Gy in total dose with 10MV x-rays (Lineac). A CT scan 4 months thereafter revealed remarkable decrease in the size of tumor and reduction of its mass effect. A CT scan 12 months later, however, revealed increase in low density area around mass, although the size of the tumor was much smaller than before. He was readmitted for surgery 14 months after irradiation. An angiogram visualized more reduction of tumor stain and the caliber of feeding arteries. The tumor was totally removed without resultant neurological deficits. A histological diagnosis of the tumor was meningotheliomatous meningioma with well developed vascular networks. Meningioma is usually not a radiosensitive tumor, but there are some reports of cases with hypervascular meningiomas which have been effectively treated with irradiation preoperatively. In the present case, because of a huge vascular tumor in the dominant hemisphere, irradiation was given initial and 14 months thereafter the tumor was totally removed without neurological deficits.

摘要

一名30岁右利手男性因头痛及右侧轻度运动无力入院,病程1年。CT扫描显示左额凸面有一肿块。脑血管造影显示一个巨大的、血管丰富的肿瘤,由双侧颈外动脉和左颈内动脉供血。由于其大小和位置,当时认为手术干预是禁忌的。相反,最初他接受了10MV X线(直线加速器)的全剂量52Gy照射。4个月后的CT扫描显示肿瘤大小显著减小,占位效应减轻。然而,12个月后的CT扫描显示肿块周围低密度区增大,尽管肿瘤大小比以前小得多。放疗14个月后他再次入院接受手术。血管造影显示肿瘤染色及供血动脉管径进一步缩小。肿瘤被完全切除,未遗留神经功能缺损。肿瘤的组织学诊断为血管网发达的脑膜皮型脑膜瘤。脑膜瘤通常不是放射敏感肿瘤,但有一些关于血管丰富型脑膜瘤术前放疗有效治疗的病例报道。在本病例中,由于优势半球有一个巨大的血管性肿瘤,先进行了放疗,14个月后肿瘤被完全切除,未出现神经功能缺损。

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