Department of Dravyaguna Vijnanam, Government Ayurveda College, Thiruvananthapuram, Kerala, India.
J Complement Integr Med. 2021 May 14;19(1):1-7. doi: 10.1515/jcim-2020-0347.
is an oleo gum resin obtained from the plant (Arn.) Bhand., used in medicines for various ailments like anti-inflammatory conditions, hyperlipidemia, thyroid disorders etc. Guggulsterones E & Z are responsible for these broad ranges of pharmacological actions. It is recommended to do (purification) before incorporating it into medicinal formulations. , an text, emphasizes the purification of Guggulu in a particular media, which is a long run practice in Kerala.
To compare the physicochemical and phytochemical parameters, quantitative estimation of Guggulsterone E & Z using high performance thin layer chromatography (HPTLC) and qualitative gas chromatography-mass spectrometry (GC-MS) analysis of Guggulu before and after purification.
of was performed in Water boiled with crushed fresh leaves of Neem () and fresh rhizome of turmeric () using a special equipment (). Preliminary physicochemical and phytochemical evaluation, quantification of Guggulsterones E & Z using HPTLC and GC-MS analysis of raw and purified were performed.
Phytochemical evaluation of metabolites revealed marked variations. The mean concentrations of Guggulsterone E & Z showed significant differences before and after purification (p<0.01). On GC-MS analysis, it was found that few new compounds were added in the purified .
Therapeutic efficacy of might have enhanced after traditional purification.
古胶树脂是从植物（Arn.）Bhand.中提取的一种油性树胶树脂，用于治疗各种疾病，如抗炎、高血脂、甲状腺疾病等。古古脂素 E 和 Z 负责这些广泛的药理作用。建议在将其纳入药物制剂之前进行（纯化）。这篇文章强调了在特定介质中对古胶进行纯化，这是喀拉拉邦的长期实践。
比较古胶在纯化前后的物理化学和植物化学参数、使用高效薄层色谱法（HPTLC）定量测定古古脂素 E 和 Z 以及古胶的气相色谱-质谱（GC-MS）分析的定性。
在沸水中用新鲜的印度楝叶（Neem（））和新鲜的姜黄根茎（）粉碎物进行古胶的纯化（），使用特殊设备（）。对古胶进行初步的物理化学和植物化学评价，使用 HPTLC 定量测定古古脂素 E 和 Z，并对原始和纯化的古胶进行 GC-MS 分析。
代谢物的植物化学评价显示出明显的差异。纯化前后古古脂素 E 和 Z 的平均浓度显示出显著差异（p<0.01）。通过 GC-MS 分析，发现纯化后的古胶中添加了一些新的化合物。
经过传统的纯化，古胶的治疗效果可能得到了增强。
