Vyas Kruti Yagneshkumar, Bedarkar Prashant, Galib R, Prajapati Pradeep Kumar
Department of Rasa Shastra and Bhaishajya Kalpana including Drug Research, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
Anc Sci Life. 2015 Oct-Dec;35(2):101-9. doi: 10.4103/0257-7941.171672.
Guggulu (Commiphora wightii [Arn.] Bhandari) is a well-known anti-hyperlipidaemic drug. Guggulsterones are active components of this drug which are responsible for this effect. The activity of Guggulu may depend upon its nature, fresh samples are recommended for their bṛhmaṇa (body mass increasing) effect; while lekhana (scarificant) effect is attributed to the old one. The comparative Anti-hyperlipidaemic activity of fresh and old samples has not been reported till date.
Freshly collected and one year old samples of Guggulu were processed in gomūtra. Patients who satisfied inclusion criteria of Hyperlipidaemia were randomly distributed into two groups and the drug was administrated in a dose of 1 g with luke warm water twice a day for eight weeks.
Significant improvement was found in the symptoms of Medoroga and Lipid profile with treatment in both the groups. Fresh sample of Guggulu proved to have a better effect in lowering serum cholesterol (5.76%), triglyceride (17.17%), and very low density lipoprotein VLDL (18.36%) levels while old sample of Guggulu provided mild effect in lowering serum triglyceride (13.64%), VLDL (11.07%) and non-significant increase in serum HDL-cholesterol (0.94%). Old sample of Guggulu also provided significant decreases in body weight (7.69%) and BMI (7.82%).
Old Guggulu showed better effect on body weight, BMI and cardinal symptoms along with significant lipid lowering effect whereas fresh Guggulu showed better result on lipid profile.
古古勒（Commiphora wightii [Arn.] Bhandari）是一种著名的降血脂药物。古古甾酮是该药物的活性成分，具有此功效。古古勒的活性可能取决于其性质，建议使用新鲜样本以发挥其滋补（增加体重）作用；而祛脂作用则归因于陈旧样本。迄今为止，尚未报道新鲜样本和陈旧样本降血脂活性的比较情况。
将新鲜采集的和存放一年的古古勒样本用牛尿处理。符合高脂血症纳入标准的患者被随机分为两组，药物以1克的剂量用温水冲服，每天两次，持续八周。
两组治疗后，梅多罗加（Medoroga）症状和血脂谱均有显著改善。新鲜古古勒样本在降低血清胆固醇（5.76%）、甘油三酯（17.17%）和极低密度脂蛋白VLDL（18.36%）水平方面效果更佳，而陈旧古古勒样本在降低血清甘油三酯（13.64%）、VLDL（11.07%）方面效果温和，且血清高密度脂蛋白胆固醇有非显著性升高（0.94%）。陈旧古古勒样本还使体重（7.69%）和BMI（7.82%）显著降低。
陈旧古古勒在降低体重、BMI和主要症状方面效果更佳，同时具有显著的降脂作用，而新鲜古古勒在血脂谱方面效果更佳。
