Innovation Center for Wound Repair, Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.
J Diabetes Investig. 2021 Nov;12(11):2099-2101. doi: 10.1111/jdi.13574. Epub 2021 Jun 6.
Both diabetes mellitus and Charcot-Marie-Tooth disease (CMT) can lead to severe peripheral neuropathy. The differential diagnosis of peripheral neuropathy is difficult due to the similar clinical features. There are still some clues, such as unusual muscle atrophy, unmatched severity of peripheral neurogenic damage with nephropathy or retinopathy, which could alert clinicians to make differential diagnosis. Although diabetes mellitus is rarely concurrent with CMT, it will exacerbate clinical disorders in patients with CMT. To date, there is no specific medicine for CMT treatment. Offloading devices and desirable comprehensive management of diabetes mellitus might be beneficial to avoid plantar ulcer recurrence and anti-progression of CMT.
糖尿病和腓骨肌萎缩症（CMT）均可导致严重的周围神经病变。由于临床特征相似，周围神经病变的鉴别诊断较为困难。仍存在一些线索，如不常见的肌肉萎缩、与肾病或视网膜病变不成比例的周围神经源性损伤严重程度，这些线索可以提醒临床医生进行鉴别诊断。虽然糖尿病很少与 CMT 同时发生，但它会使 CMT 患者的临床症状恶化。迄今为止，CMT 还没有特定的治疗药物。减压装置和理想的糖尿病综合管理可能有助于避免足底溃疡复发和 CMT 的进展。
