Rajput Rajesh, Vohra Shaweta, Nanda Smiti, Rajput Meena
Department of Endocrinology & Medicine Unit IV, Pt. B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Department of Endocrinology & Medicine Unit IV, Pt. B D Sharma Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):985-987. doi: 10.1016/j.dsx.2019.01.004. Epub 2019 Jan 16.
To estimate the level of 25 (OH)vitamin D in gestational diabetes mellitus (GDM) and to find the correlation between level of 25(OH)vitamin D and GDM.
The study was conducted on 50 diagnosed patients of GDM attending antenatal clinic in the obstetrics and gynecology department of Pt. B.D. Sharma PGIMS, Rohtak. 50 age and gestational age matched normoglycemic women were taken as control group. Procedure of study was explained to the participants and informed consent was taken.
GDM women had higher age, BMI, and positive family history of type 2 DM as compared to pregnant women without GDM. The mean vitamin D in GDM women was 32.64 ± 24.33 nmol/L while in controls it was 39.90 ± 21.86 nmol/L(P = 0.033). The prevalence of severe vitamin D deficiency(<25 nmol/L) was found to be 44% among GDM women (22 out of 50 GDM women) and 20% among women with normoglycemia (10 out of 50 normoglycemic controls) with significant p value of 0.010 and odds ratio of 1.833. GDM women with BMI>25 kg/m had 1.799 times chances to be severely deficit in vitamin D than women with BMI<25 kg/m 6 GDM women had mild vitamin D deficiency (>50 but <75 nmol/L) and 16 had moderate deficiency (>25 but <50 nmol/L). Only 6 GDM patients were found to be sufficient for vitamin D(>75 nmol/L).
Severe vitamin D deficiency in second trimester of pregnancy is significantly associated with elevated risk for GDM.
评估妊娠期糖尿病（GDM）患者血清25（OH）维生素D水平，并分析其与GDM的相关性。
选取在罗塔克市Pt. B.D. Sharma PGIMS妇产科门诊确诊的50例GDM患者。选取50例年龄及孕周匹配的血糖正常孕妇作为对照组。向研究对象解释研究流程并获得知情同意。
与非GDM孕妇相比，GDM孕妇年龄、体重指数（BMI）更高，2型糖尿病家族史阳性率更高。GDM组孕妇血清维生素D平均水平为32.64±24.33 nmol/L，对照组为39.90±21.86 nmol/L（P = 0.033）。GDM组孕妇中重度维生素D缺乏（<25 nmol/L）患病率为44%（50例GDM患者中22例），血糖正常组为20%（50例血糖正常对照者中10例），差异有统计学意义（P值为0.010，比值比为1.833）。BMI>25 kg/m²的GDM孕妇维生素D严重缺乏的可能性是BMI<25 kg/m²者的1.799倍。6例GDM孕妇存在轻度维生素D缺乏（>50但<75 nmol/L），16例存在中度缺乏（>25但<50 nmol/L）。仅6例GDM患者维生素D充足（>75 nmol/L）。
妊娠中期严重维生素D缺乏与GDM风险升高显著相关。
