College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, People's Republic of China.
Experiment and Innovation Education Center, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, People's Republic of China.
Mikrochim Acta. 2021 May 15;188(6):188. doi: 10.1007/s00604-021-04841-x.
A novel photoelectrochemical (PEC) sensor based on "Z-scheme" TiO@Au@CdS and molecularly imprinted polymer (MIP) was developed for the non-invasive detection of uric acid (UA). The "Z-scheme" material, consisting of an electron-transfer system (Au) and two isolated photochemical systems (CdS, TiO), was synthesized by chemical deposition method and it worked as a substrate for electro-polymerization of MIP. Due to the high photoelectric conversion efficiency provided by TiO@Au@CdS and specific imprinting effect afforded by MIP, the sensor displayed desirable sensing performance with the merits of sensitivity, selectivity, repeatability, and stability. The linear range for UA detection is from 1 nM to 9 μM with the detection limit of 0.3 nM (S/N = 3). Moreover, the assay was successfully utilized to measure UA in human tears and offered a reliable result. The incorporation of MIP and "Z-scheme" material into a PEC sensor system is expected to provide a promising strategy for detecting other small molecules.
一种基于“Z 型”TiO@Au@CdS 和分子印迹聚合物（MIP）的光电化学（PEC）传感器被开发用于非侵入式尿酸（UA）检测。“Z 型”材料由电子转移系统（Au）和两个隔离的光化学系统（CdS、TiO）组成，通过化学沉积法合成，并用作 MIP 电聚合的基底。由于 TiO@Au@CdS 提供的高光电转换效率和 MIP 提供的特异性印迹效应，传感器具有灵敏度、选择性、重复性和稳定性等优点，表现出理想的传感性能。UA 的检测线性范围为 1 nM 至 9 μM，检测限为 0.3 nM（S/N=3）。此外，该分析方法成功地用于测量人泪中的 UA，提供了可靠的结果。将 MIP 和“Z 型”材料纳入 PEC 传感器系统有望为检测其他小分子提供一种有前途的策略。
