Bai Xinyu, Zhang Yao, Gao Wenkai, Zhao Danyang, Yang Dapeng, Jia Nengqin
The Education Ministry Key Laboratory of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, PR China.
College of Chemical Engineering and Materials Science, Quanzhou Normal University, Quanzhou, 362000, Fujian Province, PR China.
Biosens Bioelectron. 2020 Nov 15;168:112522. doi: 10.1016/j.bios.2020.112522. Epub 2020 Aug 21.
A novel hollow ZnS-CdS nanocage-based molecularly imprinted photoelectrochemical (ZnS-CdS/rMIP PEC) sensor was designed for sensitive detection of oxytetracycline (OTC). O-phenylenediamine was electropolymerized onto hollow ZnS-CdS nanocages to form a polymer film, and then OTC molecules were imprinted on the polymer film through hydrogen bonding. When OTC was eluted, many specific recognition sites were formed on the polymer membrane for detecting OTC in samples. It is worth noting that the rhombohedral dodecahedral structure of hollow ZnS-CdS nanocage can provide large specific surface area, allowing more OTC molecules to be imprinted into the polymer film. Moreover, the unique hollow structure and the heterojunction formed by ZnS and CdS can significantly enhance the photocurrent response. Furthermore, molecular imprint polymer (MIP) technology greatly improves the selectivity and sensitivity of the constructed PEC sensor for detection of OTC. Under optimal conditions, the ZnS-CdS/rMIP PEC sensor has prominent linear relationship in the range of OTC concentration from 1 nmol L to 3 μmol L, and the detection limit is 0.10 nmol L (S/N = 3). It is gratifying that the fabricated ZnS-CdS/rMIP PEC sensor displays excellent selectivity for OTC detection when interferences with similar structure exist. It also exhibits superior reproducibility and stability as well as high recovery in the investigation of actual water samples. The combination of PEC and MIP technology will provide significant reference value for effective and rapid detection of other pollutants in the environment.
设计了一种新型的基于中空硫化锌-硫化镉纳米笼的分子印迹光电化学（ZnS-CdS/rMIP PEC）传感器，用于灵敏检测土霉素（OTC）。邻苯二胺在中空硫化锌-硫化镉纳米笼上电聚合形成聚合物膜，然后通过氢键作用将OTC分子印迹在聚合物膜上。当洗脱OTC时，聚合物膜上形成许多特异性识别位点，用于检测样品中的OTC。值得注意的是，中空硫化锌-硫化镉纳米笼的菱形十二面体结构可提供较大的比表面积，使更多的OTC分子能够印迹到聚合物膜中。此外，独特的中空结构以及硫化锌和硫化镉形成的异质结可显著增强光电流响应。此外，分子印迹聚合物（MIP）技术极大地提高了所构建的PEC传感器检测OTC的选择性和灵敏度。在最佳条件下，ZnS-CdS/rMIP PEC传感器在1 nmol/L至3 μmol/L的OTC浓度范围内具有显著的线性关系，检测限为0.10 nmol/L（S/N = 3）。令人欣慰的是，在存在结构相似干扰物的情况下，所制备的ZnS-CdS/rMIP PEC传感器对OTC检测仍显示出优异的选择性。在实际水样检测中，它还表现出卓越的重现性、稳定性以及高回收率。PEC与MIP技术的结合将为有效、快速检测环境中的其他污染物提供重要参考价值。
