Brunner H, Misgeld U
Department of Neurophysiology, Max-Planck-Institut für Psychiatrie, Planegg-Martinsried, F.R.G.
Neurosci Lett. 1988 May 16;88(1):63-8. doi: 10.1016/0304-3940(88)90316-3.
Various drugs known to affect synaptic transmission were tested for their effects on extracellular field potentials evoked in the dentate granule cell layer of guinea pig hippocampal slices. Presumptive commissural (CF) and perforant path (PP) fibers were stimulated electrically by two separate pairs of stimulating electrodes. CF stimulation elicited a field potential with a current sink and PP stimulation with a current source in the cell layer. Bath-applied carbachol (0.5-10 microM), in an atropine sensitive manner, depressed the CF-evoked field potential, but left the PP-evoked field potential unchanged. Further pharmacological testing revealed that this effect is likely to be mediated by inhibitory neurons in the dentate hilus.
对各种已知会影响突触传递的药物进行了测试，以观察它们对豚鼠海马切片齿状颗粒细胞层诱发的细胞外场电位的影响。假定的连合纤维（CF）和穿通通路（PP）纤维由两对独立的刺激电极进行电刺激。CF刺激在细胞层中引发了一个有电流汇的场电位，而PP刺激引发了一个有电流源的场电位。以阿托品敏感的方式浴加卡巴胆碱（0.5 - 10微摩尔），可抑制CF诱发的场电位，但PP诱发的场电位保持不变。进一步的药理学测试表明，这种效应可能是由齿状回门区的抑制性神经元介导的。
