Kahle J S, Cotman C W
Department of Psychobiology, University of California, Irvine 92717.
Brain Res. 1989 Mar 13;482(1):159-63. doi: 10.1016/0006-8993(89)90554-4.
The effects of applications of carbachol on evoked synaptic responses recorded in the dentate gyrus of guinea pig hippocampal slices were examined. Carbachol depressed potentials recorded extracellularly in the medial perforant path terminal zone, but did not significantly alter field potentials recorded in the lateral perforant path terminal zone. Carbachol-induced depression was reversed by applications of the muscarinic antagonists, atropine or pirenzepine. It was suggested that the difference observed in carbachol-induced depression of medial versus lateral perforant path field potentials may be due to regional differences in acetylcholine receptor distribution in the molecular layer of the dentate gyrus.
研究了卡巴胆碱应用于豚鼠海马切片齿状回中记录的诱发突触反应的效应。卡巴胆碱使在内侧穿通通路终末区细胞外记录的电位降低，但未显著改变在外侧穿通通路终末区记录的场电位。毒蕈碱拮抗剂阿托品或哌仑西平的应用可逆转卡巴胆碱诱导的抑制作用。提示在卡巴胆碱诱导的内侧与外侧穿通通路场电位抑制中观察到的差异可能是由于齿状回分子层中乙酰胆碱受体分布的区域差异所致。
