Shibuki K, Leng G, Way S
Department of Neuroendocrinology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, U.K.
Neurosci Lett. 1988 May 16;88(1):75-80. doi: 10.1016/0304-3940(88)90318-7.
Urethane anaesthetized male rats were given an i.p. injection of hypertonic saline to increase plasma osmotic pressure. This injection resulted in significantly elevated plasma oxytocin levels and increased discharge activity of putative oxytocin cells in the supraoptic nucleus. Subsequent injection of naloxone (1 mg/kg) i.v. resulted in a similarly large increase in plasma oxytocin, but did not affect the discharge activity of putative oxytocin neurones. The results suggest that, following an i.p. injection of hypertonic saline, endogenous opioids act at the neurosecretory terminals to partially inhibit oxytocin release.
用氨基甲酸乙酯麻醉雄性大鼠，腹腔注射高渗盐水以增加血浆渗透压。该注射导致血浆催产素水平显著升高，视上核中假定的催产素细胞放电活动增强。随后静脉注射纳洛酮（1毫克/千克）导致血浆催产素同样大幅增加，但不影响假定的催产素神经元的放电活动。结果表明，腹腔注射高渗盐水后，内源性阿片类物质作用于神经分泌终末，部分抑制催产素释放。
