Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), a joint venture between the Faculty of Dentistry of the University of Amsterdam and the Faculty of Dentistry of the Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Int J Dent Hyg. 2021 Nov;19(4):429-439. doi: 10.1111/idh.12517. Epub 2021 Jul 19.
To test the effectiveness of a dentifrice containing the turmeric and licorice extract compared to a control for preventing plaque and gingivitis over a four-month period.
Ninety (non-dental) participants with moderate gingival inflammation (≥ 40%) were selected. The triple blind study consisted of two phases, namely at first a 3-week pre-experimental phase of using an oxygenating and chlorhexidine (CHX) mouthrinse. Secondly, a 4-month experimental period in which participants were randomly assigned to a test or control group. All were instructed to brush their teeth twice daily for 2 minutes with their assigned dentifrice. Gingival bleeding (BI), plaque (PI) and gingivitis (GI) were assessed.
Eighty participants completed the protocol. At the first assessment in the pre-experimental phase, the mean scores of all indices showed no differences for the two groups. At the second session, the values of all three parameters had decreased significantly (p < 0.001). At the last session, the BI values were 0.52(0.25) for the test group and 0.56(0.25) for the control, the mean GI was 0.27(0.17) for the test group and 0.31(0.16) for the control, and for PI the scores were 1.89(0.46) for the test group and 1.98(0.43) for the control group. Statistical comparison of the scores for the two groups at each stage of the study showed no significant difference for any of the parameters.
Within the limits of the current study design, dentifrice formulation and concentration of turmeric/licorice extracts, the results show that the adjuvant effect of the natural ingredients in the test dentifrice was not evident on clinical parameters of gingivitis and plaque.
测试一种含有姜黄和甘草提取物的牙膏与对照物相比在预防牙菌斑和牙龈炎方面的有效性,为期四个月。
选择了 90 名(非牙科)有中度牙龈炎症(≥ 40%)的参与者。这项三盲研究包括两个阶段,首先是使用氧化和洗必泰(CHX)漱口水的 3 周预实验阶段。其次,是为期 4 个月的实验阶段,参与者被随机分配到实验组或对照组。所有参与者都被指示使用指定的牙膏每天刷牙两次,每次 2 分钟。评估牙龈出血(BI)、牙菌斑(PI)和牙龈炎(GI)。
80 名参与者完成了方案。在预实验阶段的第一次评估中,两组所有指标的平均得分没有差异。在第二次评估中,所有三个参数的值都显著下降(p<0.001)。在最后一次评估中,实验组的 BI 值为 0.52(0.25),对照组为 0.56(0.25),实验组的平均 GI 为 0.27(0.17),对照组为 0.31(0.16),PI 评分实验组为 1.89(0.46),对照组为 1.98(0.43)。对研究各个阶段两组评分的统计比较表明,任何参数都没有显著差异。
在当前研究设计、牙膏配方和姜黄/甘草提取物浓度的限制内,结果表明,实验组天然成分的辅助作用在牙龈炎和牙菌斑的临床参数上没有明显效果。