National Institutes of Health, National Library of Medicine and National Institute of Dental and Craniofacial Research, 31 Center Drive, Suite 4B62, Bethesda, MD, 20892-2190, USA.
Department of Public Health Dentistry, Amrita Vishwa Vidyapeetham, Amrita School of Dentistry, Kochi, 682041, India.
BMC Complement Med Ther. 2020 Feb 11;20(1):43. doi: 10.1186/s12906-020-2812-1.
Despite the large number of trials conducted using herbal oral care products for the reduction of dental plaque or gingivitis, results are conflicting and inconclusive.
To assess the effectiveness of herbal oral care products compared to conventional products in reducing dental plaque and gingivitis adults.
We searched the following databases for Randomised controlled trials (RCTs): MEDLINE Ovid, EMBASE Ovid etc. which yielded 493 trails. Of which 24 RCTs comparing herbal toothpaste or mouth rinse with over the counter toothpaste or mouth rinse in adults aged 18 to 65 years were included. Two authors extracted information and assessed the methodological quality of the included studies using Risk of Bias. Meta-analyses using the random-effects model were conducted for four outcomes for tooth paste and mouth rinse respectively. Mean difference (MD) or standardized mean difference (SMD) were used to estimate the effect, with 95% confidence intervals.
A total of 1597 adults participated in 24 RCT studies. These were classified as herbal toothpaste (HTP) (15 trials, 899 participants) and herbal mouth rinse (HMR) (9 trials, 698 participants) compared with non-herbal toothpaste (NHTP) or non-herbal mouth rinse (NHMR). We found that HTP was superior over NHTP (SMD 1.95, 95% CI (0.97-2.93)) in plaque reduction. The long-term use of NHMR was superior in reduction of dental plaque over HMR (SMD -2.61, 95% (CI 4.42-0.80)). From subgroup analysis it showed that HTP was not superior over fluoride toothpaste (SMD 0.99, 95% CI (0.14-2.13)) in reducing dental plaque. However, HTP was favoured over non-fluoride toothpaste (SMD 4.64, 95% CI (2.23-7.05)).
For short-term reduction in dental plaque, current evidence suggests that HTP is as effective as compared to NHTP; however, evidence is from low quality studies.
尽管已经进行了大量使用草药口腔护理产品来减少牙菌斑或牙龈炎的试验，但结果相互矛盾，尚无定论。
评估与传统产品相比，草药口腔护理产品在减少成人牙菌斑和牙龈炎方面的有效性。
我们在以下数据库中搜索了随机对照试验（RCT）：MEDLINE Ovid、EMBASE Ovid 等，共产生了 493 项试验。其中包括 24 项 RCT，比较了成人（年龄 18-65 岁）使用草药牙膏或漱口水与市售牙膏或漱口水的效果。两位作者提取信息，并使用风险偏倚评估纳入研究的方法学质量。分别对牙膏和漱口水的四个结局进行了随机效应模型的荟萃分析。使用均值差（MD）或标准化均值差（SMD）来估计效果，置信区间为 95%。
共有 1597 名成年人参与了 24 项 RCT 研究。这些研究分为草药牙膏（HTP）（15 项试验，899 名参与者）和草药漱口水（HMR）（9 项试验，698 名参与者）与非草药牙膏（NHTP）或非草药漱口水（NHMR）进行比较。我们发现 HTP 在减少牙菌斑方面优于 NHTP（SMD 1.95，95%CI（0.97-2.93））。长期使用 NHMR 在减少牙菌斑方面优于 HMR（SMD-2.61，95%CI（4.42-0.80））。从亚组分析来看，HTP 在减少牙菌斑方面并不优于含氟牙膏（SMD 0.99，95%CI（0.14-2.13））。然而，HTP 优于不含氟牙膏（SMD 4.64，95%CI（2.23-7.05））。
就短期减少牙菌斑而言，目前的证据表明，HTP 与 NHTP 一样有效；然而，证据来自低质量的研究。
