Rossi F, Chelazzi L, Tempia F, Strata P
Department of Human Anatomy and Physiology, University of Turin, Italy.
Neurosci Lett. 1988 Jun 17;89(1):69-73. doi: 10.1016/0304-3940(88)90482-x.
Following an intraperitoneal injection of ethanol (1 g/kg), spontaneous saccades performed by pigmented rats showed a backward post-saccadic drift which was still present 45 min after the administration. When 5 mg/kg of Ro 15-4513 were injected, 15 min after ethanol, there was an immediate remarkable reduction in post-saccadic drift amplitude, with a full recovery in about 30 min after Ro 15-4513 administration. This drug is thus able to reverse the effect of ethanol and to restore effectively a mechanism of motor integration.
给有色大鼠腹腔注射乙醇（1克/千克）后，其自发扫视运动出现扫视后向后漂移，给药后45分钟仍存在。乙醇给药15分钟后注射5毫克/千克的Ro 15 - 4513，扫视后漂移幅度立即显著降低，Ro 15 - 4513给药后约30分钟完全恢复。因此，这种药物能够逆转乙醇的作用，并有效恢复运动整合机制。
