Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.
Hyvinkää Hospital, Endoscopy Outpatient Clinic, Hyvinkää, Finland.
Neurogastroenterol Motil. 2022 Feb;34(2):e14171. doi: 10.1111/nmo.14171. Epub 2021 May 15.
Behavioral therapy (BT) has been proven effective in the treatment of supragastric belching (SGB) in open studies. The aim was to compare BT to follow-up without intervention in patients with SGB in a randomized study.
Forty-two patients were randomized to receive 5 sessions of BT, comprising diaphragmatic breathing exercises, or to follow-up without intervention. Patients were evaluated at 6 months, at which point the control group was also offered BT and evaluated after another 6 months. The frequency and intensity of belching and mental well-being were evaluated with a visual analog scale (VAS). Depression, anxiety, and health-related quality of life (HRQoL) were evaluated with four questionnaires: BDI, BAI, 15D, and RAND-36.
The frequency and intensity of SGB were significantly lower in the therapy group (n = 19) than in the control group (n = 18) at the 6-month control (p < 0.001). When all patients (n = 36) were evaluated 6 months after BT, in addition to relief in the frequency and intensity of belching (p < 0.001), mental well-being had also improved (p < 0.05). Of all 36 patients, 27(75%) responded to BT. Depression scores were lower after therapy (p < 0.05). Only minor changes occurred in anxiety and HRQoL.
Behavioral therapy is superior to follow-up without intervention in patients with SGB in reducing belching and depression; it also improves mental well-being but has only a modest effect on anxiety and HRQoL.
行为疗法（BT）已被证明在开放性研究中对胃食管上打嗝（SGB）的治疗有效。目的是在一项随机研究中比较 BT 与无干预的随访在 SGB 患者中的疗效。
42 名患者随机分为接受 5 次 BT 治疗组，包括膈肌呼吸练习，或无干预的随访组。患者在 6 个月时进行评估，此时对照组也提供 BT 治疗并在另外 6 个月后进行评估。打嗝的频率和强度以及心理健康状况用视觉模拟评分（VAS）进行评估。抑郁、焦虑和健康相关生活质量（HRQoL）用四个问卷评估：BDI、BAI、15D 和 RAND-36。
在 6 个月的对照组中，治疗组（n=19）的 SGB 频率和强度明显低于对照组（n=18）（p<0.001）。当所有患者（n=36）在 BT 治疗后 6 个月进行评估时，除了打嗝频率和强度缓解（p<0.001）外，心理健康状况也得到改善（p<0.05）。在所有 36 名患者中，有 27 名（75%）对 BT 有反应。治疗后抑郁评分降低（p<0.05）。焦虑和 HRQoL 只有微小变化。
在减少打嗝和抑郁方面，行为疗法优于 SGB 患者的无干预随访；它还改善了心理健康，但对焦虑和 HRQoL 的影响较小。
