College of Basic Medical Sciences, Dalian Medical University, 9-Western Section, Lvshun South Road, Dalian, Liaoning, 116044, China.
College of Basic Medical Sciences, Dalian Medical University, 9-Western Section, Lvshun South Road, Dalian, Liaoning, 116044, China.
Brain Res Bull. 2021 Aug;173:116-123. doi: 10.1016/j.brainresbull.2021.05.009. Epub 2021 May 12.
Sialylation, one of the most common and complex modes of glycosylation, corresponds with the development of the infant brain and nervous system. The most prevalent neurodegenerative disease is Alzheimer's disease (AD), which is mainly characterized by cognitive decline and behavioral disorders. However, the relationship between sialylation and AD occurrence is poorly understood. In this article, we reviewed the role of sialylation on the occurrence and development of AD, then discussed the value of sialylation modification for AD diagnosis and treatment.
唾液酸化是最常见和最复杂的糖基化方式之一，与婴儿大脑和神经系统的发育有关。最常见的神经退行性疾病是阿尔茨海默病（AD），其主要特征是认知能力下降和行为障碍。然而，唾液酸化与 AD 发生之间的关系尚不清楚。在本文中，我们综述了唾液酸化在 AD 发生和发展中的作用，然后讨论了唾液酸化修饰在 AD 诊断和治疗中的价值。
