Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Curr Opin Microbiol. 2021 Aug;62:1-7. doi: 10.1016/j.mib.2021.04.005. Epub 2021 May 12.
Disseminated candidiasis is a hospital-acquired infection that results in high degree of mortality despite antifungal treatment. Autopsy studies revealed that kidneys are the major target organs in disseminated candidiasis and death due to kidney damage is a frequent outcome in these patients. Thus, the need for effective therapeutic strategies to mitigate kidney damage in disseminated candidiasis is compelling. Recent studies have highlighted the essential contribution of kidney-specific immune response in host defense against systemic infection. Crosstalk between kidney-resident and infiltrating immune cells aid in the clearance of fungi and prevent tissue damage in disseminated candidiasis. In this review, we provide our recent understanding on antifungal immunity in the kidney with an emphasis on IL-17-mediated renal defense in disseminated candidiasis.
播散性念珠菌病是一种医院获得性感染，尽管进行了抗真菌治疗，但仍导致高死亡率。尸检研究表明，肾脏是播散性念珠菌病的主要靶器官，这些患者因肾脏损害而死亡是常见的结果。因此，迫切需要有效的治疗策略来减轻播散性念珠菌病中的肾脏损害。最近的研究强调了肾脏特异性免疫反应在宿主防御全身感染中的重要贡献。肾脏固有免疫细胞和浸润免疫细胞之间的相互作用有助于清除真菌并防止播散性念珠菌病中的组织损伤。在这篇综述中，我们提供了我们最近对肾脏中抗真菌免疫的理解，重点介绍了 IL-17 介导的播散性念珠菌病中的肾脏防御。
