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大网膜巨大良性神经鞘瘤合并同步宫颈癌:一例报告。

Large benign schwannoma of the greater omentum with synchronous cervical cancer: A case report.

作者信息

Yap Ralph Victor, Santos Al Marion, Roble Vincent Matthew

机构信息

Department of Surgery, Cebu Doctors' University Hospital, Cebu City, Philippines.

Department of Surgery, Cebu Doctors' University Hospital, Cebu City, Philippines.

出版信息

Int J Surg Case Rep. 2021 Jun;83:105961. doi: 10.1016/j.ijscr.2021.105961. Epub 2021 May 9.

Abstract

INTRODUCTION AND IMPORTANCE

Schwannomas are uncommon tumors of the omentum with only 16 reported cases originating from the greater omentum in the literature. We report for the first time a synchronous presentation of an omental schwannoma and cervical cancer.

CASE PRESENTATION

A 37-year-old female presented with an abdominal mass and heavy vaginal bleeding. An 11.5 × 14.6 × 16.6 cm complex omental mass and 5.4 × 6.2 × 4.4 cm lobulated heterogeneous cervical mass were noted on CT-scan. Wide excision of the complex mass and radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymph node dissection was performed. The final biopsy revealed benign omental schwannoma and poorly differentiated cervical adenocarcinoma.

CLINICAL DISCUSSION

Schwannomas originating from the greater omentum are less common than in the lesser omentum due to the paucity of nervous tissue in the former. They can undergo malignant transformation and the most common presentation is abdominal pain/discomfort. Larger tumors may cause catastrophic bleeding. Prompt surgery should be offered and wide local excision with sufficient margins be performed when there is suspicion of malignancy. Schwannomas presenting with multiple or synchronous lesions are commonly associated with neurofibromatosis type 2, schwannomatosis, and Carney's complex. Whether this co-occurrence is simply incidental or has a causal relationship remains to be established.

CONCLUSION

Benign schwannoma of the greater omentum is rare and only requires complete tumor excision. However, surgeons should be aware that synchronous presentation of cervical cancer is possible and that thorough examination of both sites should be undertaken when either primary tumor presents.

摘要

引言与重要性

神经鞘瘤是一种罕见的大网膜肿瘤,文献中仅报道了16例起源于大网膜的病例。我们首次报告了一例大网膜神经鞘瘤与宫颈癌同时出现的病例。

病例介绍

一名37岁女性因腹部肿块和大量阴道出血就诊。CT扫描发现一个11.5×14.6×16.6cm的复杂大网膜肿块和一个5.4×6.2×4.4cm的分叶状不均匀宫颈肿块。对复杂肿块进行了广泛切除,并进行了根治性子宫切除术、双侧输卵管卵巢切除术和盆腔淋巴结清扫术。最终活检显示为良性大网膜神经鞘瘤和低分化宫颈腺癌。

临床讨论

由于大网膜中神经组织较少,起源于大网膜的神经鞘瘤比起源于小网膜的更为少见。它们可发生恶性转化,最常见的表现是腹痛/不适。较大的肿瘤可能导致灾难性出血。当怀疑有恶性肿瘤时,应及时进行手术,并进行足够切缘的广泛局部切除。出现多个或同时存在的病变的神经鞘瘤通常与2型神经纤维瘤病、神经鞘瘤病和卡尼综合征有关。这种同时出现是单纯偶然还是存在因果关系仍有待确定。

结论

大网膜良性神经鞘瘤罕见,仅需完整切除肿瘤。然而,外科医生应意识到可能同时出现宫颈癌,当出现任何一种原发性肿瘤时,都应对两个部位进行全面检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db10/8134983/d43d7ad98ffb/gr1.jpg

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