Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
School of Pharmacy, Xi'an Jiaotong University, Shaanxi Key Laboratory of "Qiyao" Resources and Anti-Tumor Acitivities, Xi'an, 710061, China.
Pathol Res Pract. 2021 Jul;223:153475. doi: 10.1016/j.prp.2021.153475. Epub 2021 May 10.
In our previous study, we reported that the long noncoding RNA, LMO7 downstream neighbor (LMO7DN), has a strong prognostic value in lung adenocarcinoma (LUAD). In this study, we further investigated the role of LMO7DN in LUAD progression. LMO7DN was found to be expressed at low levels in LUAD tissues, and its high expression predicted good prognosis. Bioinformatics analysis indicated that LMO7DN was closely associated with the cell cycle. Furthermore, we found that cell proliferation was significantly enhanced following knockdown of LMO7DN, and the number of cells in the G2/M phase was markedly decreased, whereas there was no change in apoptosis. Thus, LMO7DN inhibits cell proliferation by affecting the cell cycle and is of significant prognostic value in LUAD.
在我们之前的研究中，我们报道了长非编码 RNA，LMO7 下游邻居（LMO7DN）在肺腺癌（LUAD）中具有很强的预后价值。在这项研究中，我们进一步研究了 LMO7DN 在 LUAD 进展中的作用。发现 LMO7DN 在 LUAD 组织中表达水平较低，其高表达预示着良好的预后。生物信息学分析表明，LMO7DN 与细胞周期密切相关。此外，我们发现敲低 LMO7DN 后细胞增殖显著增强，G2/M 期细胞数量明显减少，而凋亡没有变化。因此，LMO7DN 通过影响细胞周期抑制细胞增殖，对 LUAD 具有重要的预后价值。
