脑膜瘤：一般特征、组织病理学、临床和分子特征的综述。
Meningiomas: A review of general, histopathological, clinical and molecular characteristics.
机构信息
Department of Pathology, Universidade Federal de São Paulo, Escola Paulista, de Medicina, Botucatu Street, 740, Vila Clementino, São Paulo, SP, Brazil; Laboratory of Molecular and Experimental Pathology, Universidade Federal, de São Paulo, Escola Paulista de Medicina, Pedro de Toledo Street, 781, 5º Floor - Vila Clementino, São Paulo, SP, Brazil.
Escola Paulista de Enfermagem, Universidade Federal de São Paulo, Napoleão de Barros Street, 754 - Vila Clementino, São Paulo, SP, Brazil.
出版信息
Pathol Res Pract. 2021 Jul;223:153476. doi: 10.1016/j.prp.2021.153476. Epub 2021 May 10.
OBJECTIVES
In this review, the main histological and molecular characteristics of meningiomas will be addressed, as well as the aspects most related to clinical conditions, treatment, and survival of patients, enabling a better understanding of these tumors behavior.
METHODS
This study was conducted with the search for published studies available on NCBI, PubMed, MEDLINE, Scielo and Google Scholar. Relevant documents have been identified and 50 articles were selected.
RESULTS
The main points about meningiomas were characterized, as well as the histological presence of spontaneous necrosis in grade I and brain invasion as diagnostic criteria, their molecular origin related to deletion of chromosome 22 and mutations in theNF2 and TERT genes, in addition to their clinical characteristics. The preferential treatment remains the total resection of the tumor.
CONCLUSION
The information about meningiomas is well known and necessary, but it is expected that more work will emerge related to the behavior of these tumors, and that the scientific community will obtain more clarity about the best ways to conduct the patients treatment.
目的
在这篇综述中，将讨论脑膜瘤的主要组织学和分子特征，以及与患者的临床状况、治疗和生存最相关的方面，以便更好地了解这些肿瘤的行为。
方法
本研究通过在 NCBI、PubMed、MEDLINE、Scielo 和 Google Scholar 上搜索已发表的研究进行。已确定相关文件并选择了 50 篇文章。
结果
脑膜瘤的主要特点得到了描述，以及 I 级和脑侵犯作为诊断标准的组织学存在自发性坏死，其分子起源与染色体 22 的缺失和 NF2 和 TERT 基因的突变有关，此外还有其临床特征。首选的治疗方法仍然是肿瘤的完全切除。
结论
关于脑膜瘤的信息是众所周知且必要的，但预计将有更多与这些肿瘤行为相关的工作出现，科学界将对如何为患者进行治疗获得更多的明确性。
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