4th Department of Internal Medicine, Medical Faculty of University of PJ Safarik, Kosice, Slovakia.
1st Department of Internal Medicine, Medical Faculty of University of PJ Safarik, Kosice, Slovakia.
Endocr Metab Immune Disord Drug Targets. 2022 Aug 15;22(7):728-737. doi: 10.2174/1871530321666210516000042.
The population worldwide is largely exposed to bisphenol A (BPA), a commonly used plasticizer, that has a similar molecular structure to endogenous estrogens. Therefore, it is able to influence physiological processes in the human body, taking part in pathophysiology of various endocrinopathies, as well as, cardiovascular, neurological and oncological diseases. BPA has been found to affect the immune system, leading to the development of autoimmunity and allergies, too. In the last few decades, the prevalence of autoimmune diseases has significantly increased that could be explained by a rising exposure of the population to environmental factors, such as BPA. BPA has been found to play a role in the pathogenesis of systemic autoimmune diseases and also organ-specific autoimmunity (thyroid autoimmunity, diabetes mellitus type 1, myocarditis, inflammatory bowel disease, multiple sclerosis, encephalomyelitis etc), but the results of some studies still remain controversial, so further research is needed.
全世界的人口都大量接触到双酚 A（BPA），一种常用的塑化剂，它具有与内源性雌激素相似的分子结构。因此，它能够影响人体的生理过程，参与各种内分泌疾病的病理生理学，以及心血管、神经和肿瘤疾病。已经发现 BPA 会影响免疫系统，导致自身免疫和过敏的发展。在过去几十年中，自身免疫性疾病的患病率显著增加，这可以用人口接触环境因素（如 BPA）的增加来解释。已经发现 BPA 在全身性自身免疫性疾病和器官特异性自身免疫（甲状腺自身免疫、1 型糖尿病、心肌炎、炎症性肠病、多发性硬化、脑炎等）的发病机制中起作用，但一些研究的结果仍然存在争议，因此需要进一步研究。
