Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan.
Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8560, Japan.
J Cardiol. 2021 Sep;78(3):250-254. doi: 10.1016/j.jjcc.2021.04.006. Epub 2021 May 13.
A poor nutritional status of patients before transcatheter aortic valve implantation (TAVI) has been reported to be associated with poor clinical outcomes. However, changes in the nutritional status following TAVI have not been fully elucidated.
In this single-center retrospective observational study, 129 patients whose nutritional status at baseline and 6 months after TAVI were available were investigated. The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) were used to assess the nutritional status of the patients at baseline and at 6 months. We further assessed changes in the nutritional status of patients in the subgroups stratified according to the baseline levels as low and high.
The PNI and GNRI values at 6 months were significantly better than at baseline [PNI, baseline: 44.5 (41.0-48.0), 6 months: 46.0 (41.9-48.3), p = 0.02; GNRI, baseline: 95.3 (89.0-100.3), 6 months: 97.8 (91.5-101.4), p = 0.006]. Both PNI and GNRI values at 6 months were significantly better in the patients with a low baseline nutritional status, while no significant change was observed in those with high baseline levels [PNI, low; baseline: 36.8 (36.1-39.4), 6 months: 40.8 (39.0-43.4), p = 0.002, high; baseline: 47.0 (43.0-49.5), 6 months: 46.5 (43.5-50.5), p = 0.44 and GNRI, low; baseline: 86.4 (81.7-88.7), 6 months: 88.6 (83.4-95.3), p = 0.001, high; baseline: 99.8 (95.3-102.8), 6 months: 100.7 (96.8-103.4), p = 0.34].
Nutritional status of patients might improve during the chronic phase after TAVI, especially in those with poor baseline levels.
据报道,经导管主动脉瓣植入术(TAVI)前患者的营养状况较差与临床结局较差有关。然而,TAVI 后营养状况的变化尚未完全阐明。
在这项单中心回顾性观察性研究中,调查了 129 名患者的基线和 TAVI 后 6 个月的营养状况。使用预后营养指数(PNI)和老年营养风险指数(GNRI)评估患者基线和 6 个月时的营养状况。我们还根据基线低值和高值对患者进行分层,进一步评估了患者营养状况的变化。
6 个月时的 PNI 和 GNRI 值明显优于基线值[PNI,基线:44.5(41.0-48.0),6 个月:46.0(41.9-48.3),p=0.02;GNRI,基线:95.3(89.0-100.3),6 个月:97.8(91.5-101.4),p=0.006]。基线营养状况较低的患者 6 个月时的 PNI 和 GNRI 值均明显改善,而基线水平较高的患者则无明显变化[PNI,低值;基线:36.8(36.1-39.4),6 个月:40.8(39.0-43.4),p=0.002,高值;基线:47.0(43.0-49.5),6 个月:46.5(43.5-50.5),p=0.44;GNRI,低值;基线:86.4(81.7-88.7),6 个月:88.6(83.4-95.3),p=0.001,高值;基线:99.8(95.3-102.8),6 个月:100.7(96.8-103.4),p=0.34]。
TAVI 后慢性期患者的营养状况可能会改善,尤其是基线水平较差的患者。