英国的阿片类药物：在 COVID-19 期间的安全性和监测。
Opioids in the United Kingdom: safety and surveillance during COVID-19.
机构信息
Drug Safety Research Unit, Southampton.
School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK.
出版信息
Curr Opin Psychiatry. 2021 Jul 1;34(4):357-362. doi: 10.1097/YCO.0000000000000719.
PURPOSE OF REVIEW
Opioid use is prevalent in the United Kingdom and prior to the COVID-19 pandemic it had been recognized that the safety of opioids was an important issue to be monitored by the UK medicines regulatory agency. With the emergence of COVID-19, this requirement has been even greater. This review was undertaken to determine the impact of the pandemic on safety and surveillance of opioids in the United Kingdom.
RECENT FINDINGS
During the COVID-19 pandemic, the surveillance of opioids in the United Kingdom continued, although primary research was often conducted with data prior to the pandemic. Of those studies that were conducted while the pandemic was ongoing, access to opioids (or opioid substitution therapy) and the subsequent effect on patient safety was the main theme.
SUMMARY
In the United Kingdom, changes in accessibility to the healthcare system and how healthcare providers operated during the COVID-19 pandemic may have had unintended consequences on use and safety of opioids, due to the shift in focus to preventing COVID-19 from overwhelming the healthcare system. The findings from this review support the need to continue surveillance in the United Kingdom, including the impact of the COVID-19 pandemic on opioid utilization and safety.
目的综述
阿片类药物在英国的使用很普遍，在 COVID-19 大流行之前，英国药品监管机构已经认识到监测阿片类药物的安全性是一个重要问题。随着 COVID-19 的出现，这一需求变得更加迫切。本综述旨在确定大流行对英国阿片类药物安全性和监测的影响。
最近的发现
在 COVID-19 大流行期间，英国继续对阿片类药物进行监测，尽管主要研究通常是在大流行之前的数据进行的。在大流行期间进行的研究中，阿片类药物（或阿片类药物替代疗法）的可及性及其对患者安全的后续影响是主要主题。
总结
在英国，由于医疗系统重心转移到防止 COVID-19 使医疗系统不堪重负，COVID-19 大流行期间医疗系统可及性以及医疗服务提供者运作方式的变化，可能对阿片类药物的使用和安全性产生了意外的后果。本综述的结果支持英国继续进行监测的必要性，包括 COVID-19 大流行对阿片类药物使用和安全性的影响。
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