严重急性呼吸综合征冠状病毒 2 （SARS-CoV-2）-初治疗养院居民中 BNT162b2 信使 RNA 疫苗反应降低。

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Naive Nursing Home Residents.

机构信息

Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Geriatric Research, Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.

出版信息

Clin Infect Dis. 2021 Dec 6;73(11):2112-2115. doi: 10.1093/cid/ciab447.

DOI:10.1093/cid/ciab447

PMID:33993265

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8240817/

Abstract

After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-naive nursing home residents' median post-second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2-naive healthcare workers.

摘要

在接受 BNT162b2 信使 RNA 疫苗接种后，对 149 名养老院居民和 110 名医护人员对照者的刺突、受体结合域和病毒中和抗体水平进行了检测。未感染过严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的养老院居民第二次疫苗接种后抗体中和滴度中位数为未感染过 SARS-CoV-2 的医护人员的四分之一。