Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, School of Paediatric Dentistry- Dental Clinic, University of Brescia, ASST-Spedali Civili of Brescia, 25133, Brescia, Italy.
University Vita-Salute S. Raffaele, 10090, Milan, Italy.
Ir J Med Sci. 2022 Apr;191(2):801-805. doi: 10.1007/s11845-021-02621-3. Epub 2021 May 15.
The aim of this study was to investigate the therapies administered to Italian adolescents with primary herpetic gingivostomatitis (PHGS) METHODS: The medical records of 74 adolescents with PHSG were reviewed. The following data were recorded: age, gender, day of onset, type of treatment, lesions' severity, pain scoring, eating, and drinking ability. The oral examination was performed at the first evaluation (T0) and after one week (T1).
All patients showed up at the first visit at least 48 h after the onset of symptoms. No patient was prescribed an antiviral therapy. An antibiotic therapy was prescribed in order to prevent secondary bacterial infections. Fifteen patients had been treated with non alcoholic chlorhexidine rinses (group A), 29 patients with non alcoholic chlorhexidine rinses plus hyaluronic acid gel (group B); 30 patients with non alcoholic chlorhexidine rinses plus Mucosyte® (group C). A significant improvement of the pain scoring and lesions' severity was noted in group C.
In Italian adolescents, PHGS is diagnosed at least 48 h after onset and the antibiotic therapy is widely prescribed in order to prevent overinfections. Among topical therapies, an association of verbascoside and sodium hyaluronhate seems to favour a faster healing.
本研究旨在调查意大利原发性疱疹性龈口炎(PHGS)青少年的治疗方法。
回顾了 74 例 PHGS 青少年的病历。记录了以下数据:年龄、性别、发病日、治疗类型、病变严重程度、疼痛评分、进食和饮水能力。口腔检查在第一次评估(T0)和一周后(T1)进行。
所有患者在出现症状后至少 48 小时才到首次就诊。没有患者接受抗病毒治疗。为了预防继发细菌感染,开具了抗生素治疗。15 例患者使用非酒精性洗必泰漱口水(A 组),29 例患者使用非酒精性洗必泰漱口水加透明质酸凝胶(B 组);30 例患者使用非酒精性洗必泰漱口水加 Mucosyte®(C 组)。C 组患者的疼痛评分和病变严重程度明显改善。
在意大利青少年中,PHGS 在发病后至少 48 小时才被诊断出来,并且广泛开具抗生素治疗以预防过度感染。在局部治疗中,verbascoside 和透明质酸钠的联合应用似乎有利于更快愈合。