阿米替林和米安色林对配对联想学习任务习得的影响。
Amitriptyline- and mianserin-induced changes in acquisition of paired-association learning-task.
作者信息
Liljequist R, Seppälä T, Mattila M J
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):149-53. doi: 10.1111/j.1365-2125.1978.tb01616.x.
Abstract
1 The double-blind study on twenty healthy students was an attempt at assessing the effects of 2-week's treatment with amitriptyline (25 mg three times a day) and mianserin (10 mg three times a day), each alone or separatively inbibed with alcohol (0.5 g/kg) on the immediate memory and on the acquisition of a paired-association learning-task. 2 Amitriptyline impaired both the short-term memory-span and acquisition, and alcohol potentiated these effects. The action of mianserin did not deviate significantly from that of the placebo, and it also failed to interact with alcohol. 3 It is concluded that the decrement in learning capacity, that occurs after the 2-week's treatment with therapeutic doses of amitriptyline, reflects changes in both the intrinsic and the regulatory mechanisms of learning.
摘要
- 这项针对20名健康学生的双盲研究旨在评估阿米替林（每日三次，每次25毫克）和米安色林（每日三次，每次10毫克）单独使用或分别与酒精（0.5克/千克）同时摄入，对即时记忆和配对联想学习任务获取的影响，为期两周。2. 阿米替林损害了短期记忆广度和学习能力，酒精增强了这些影响。米安色林的作用与安慰剂相比无显著差异，且它也未与酒精发生相互作用。3. 得出的结论是，用治疗剂量的阿米替林进行两周治疗后出现的学习能力下降，反映了学习的内在机制和调节机制的变化。
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Amitriptyline- and mianserin-induced changes in acquisition of paired-association learning-task.阿米替林和米安色林对配对联想学习任务习得的影响。
Br J Clin Pharmacol. 1978 Feb;5(2):149-53. doi: 10.1111/j.1365-2125.1978.tb01616.x.
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