Valdecilla Biomedical Research Institute (IDIVAL), Santander, Spain.
Faculty of Psychology, Complutense University of Madrid, Spain.
Psychol Psychother. 2021 Sep;94(3):523-540. doi: 10.1111/papt.12327. Epub 2021 May 16.
The aim of this study was to examine the sociodemographic and clinical differences between people with a probable diagnosis of panic disorder (PD) and those with PD and a probable comorbid diagnosis major depressive disorder (PD + MDD). We also sought to explore the potential contribution of cognitive variables to help differentiate between PD and PD + MDD. This was a subgroup analysis of 331 patients with PD symptoms who were included in the PsicAP clinical trial. All participants completed scales to evaluate panic, depression, somatization, cognitive and performance variables. A univariate analysis showed significant differences (p < .01) between the groups (PD vs PD + MDD) in clinical variables. Somatization was the best predictor of comorbid PD + MDD (β = .346; p < .01). Cognitive variables do not appear to play an essential role in predicting the presence of depressive symptoms in people with a screen positive for PD. These findings appear to support a transdiagnostic treatment approach for PD, which may be useful regardless of whether comorbid depression is present or not. PRACTITIONER POINTS: Somatic symptoms were associated with a higher probability of be in the PD + MDD group. Cognitive variables do not play a relevant role in the differentiation of both groups. A transdiagnostic approach can be useful for the treatment of PD or PD + MDD group.
本研究旨在探讨可能患有惊恐障碍（PD）的人群与 PD 合并可能诊断为重度抑郁障碍（PD+MDD）的人群之间在社会人口学和临床方面的差异。我们还试图探讨认知变量对帮助区分 PD 和 PD+MDD 的潜在贡献。这是在 PsicAP 临床试验中纳入的 331 名有 PD 症状的患者的亚组分析。所有参与者都完成了评估惊恐、抑郁、躯体化、认知和表现变量的量表。单变量分析显示，在临床变量方面，两组（PD 与 PD+MDD）之间存在显著差异（p<.01）。躯体化是 PD+MDD 合并症的最佳预测因子（β=.346；p<.01）。认知变量似乎在预测对 PD 筛查阳性人群中抑郁症状的出现方面没有起到重要作用。这些发现似乎支持 PD 的跨诊断治疗方法，无论是否存在合并抑郁，这种方法都可能有用。临床医生要点：躯体症状与更有可能属于 PD+MDD 组相关。认知变量在两组的区分中没有起到相关作用。跨诊断方法对 PD 或 PD+MDD 组的治疗可能有用。
