Overbeek Thea, Schruers Koen, van Leeuwen Ine Docters, Klaassen Tineke, Griez Eric
Academic Anxiety Center, Psychiatric Hospital Vijverdal, Maastricht, The Netherlands.
Can J Psychiatry. 2005 Mar;50(3):175-8. doi: 10.1177/070674370505000307.
To date, carbon dioxide (CO2) challenge tests in panic disorder (PD) patients have focused on anxiety as the sole outcome measure. This study assesses a broader range of symptoms in patients with PD.
We administered a gas mixture of 35% CO2 and 65% oxygen (O2) to 25 patients with PD. Nine patients met the criteria for a comorbid major depressive disorder (MDD), and 16 did not. We assessed not only subjects' symptoms of anxiety but also their symptoms of depression and aggression.
Baseline ratings did not differ across the 2 subgroups. Postchallenge ratings were higher for PD and MDD patients on all the assessed affective symptoms, except for specific panic symptoms.
These findings suggest that, in addition to anxiety, CO2 challenge induces depressive and aggressive symptoms, specifically in PD patients with comorbid depression.
迄今为止，惊恐障碍（PD）患者的二氧化碳（CO₂）激发试验一直将焦虑作为唯一的结果指标。本研究评估了PD患者更广泛的症状范围。
我们对25名PD患者给予了35% CO₂和65%氧气（O₂）的混合气体。9名患者符合共病重度抑郁症（MDD）的标准，16名患者不符合。我们不仅评估了受试者的焦虑症状，还评估了他们的抑郁和攻击症状。
两个亚组的基线评分没有差异。除特定的惊恐症状外，PD和MDD患者在所有评估的情感症状方面激发后评分更高。
这些发现表明，除焦虑外，CO₂激发还会诱发抑郁和攻击症状，特别是在伴有抑郁症的PD患者中。
