Department of Obstetrics, Center for Pregnant Women with Diabetes, Rigshospitalet, 2100 Copenhagen, Denmark.
Department of Endocrinology, The Diabetes & Bone metabolic Research Unit, Rigshospitalet, 2100 Copenhagen, Denmark.
Epigenomics. 2021 Jun;13(12):967-980. doi: 10.2217/epi-2021-0015. Epub 2021 May 17.
To investigate the association between maternal post-traumatic stress disorder (PTSD) during pregnancy and offspring DNA methylation and cortisol levels. Blood genome-wide DNA methylation and cortisol was measured in the youngest child of 117 women who experienced sexual violence/torture during the Kosovo war. Seventy-two percent of women had PTSD symptoms during pregnancy. Their children had higher cortisol levels and differential methylation at candidate genes (, and ) No methylation differences reached epigenome-wide corrected significance levels. Identifying the biological processes whereby the negative effects of trauma are passed across generations and defining groups at high risk is a key step to breaking the intergenerational transmission of the effects of mental disorders.
探讨孕妇创伤后应激障碍（PTSD）与后代 DNA 甲基化和皮质醇水平之间的关联。
研究人员检测了在科索沃战争期间遭受性暴力/酷刑的 117 名女性中最年幼孩子的血液全基因组 DNA 甲基化和皮质醇水平。72%的女性在怀孕期间出现 PTSD 症状。她们的孩子皮质醇水平较高，候选基因（、和）的 DNA 甲基化存在差异。但没有达到全基因组校正显著水平的甲基化差异。
确定创伤的负面影响在代际间传递的生物学过程，并确定处于高风险的群体，是打破精神障碍影响代际传递的关键步骤。
